PPT-Purine and pyrimidine catabolism

Purine catabolism Purine degradation Purine Salvage Pathway From normal turnover of cellular nucleic acids Obtained from the diet Reutilization of adenine hypoxanthine and guanine Two enzymes. DNA: Picture 51. http://info.bio.cmu.edu/courses/03231/ProtStruc/ProtStruc.htm. B-DNA: The advent of modeling. http://molvis.sdsc.edu/pdb/dna_b_form.pdb. 46 Å. . 12 base sequence. (1953-2003). DNA: Size, Shape & Self Assembly. OBJECTIVES:. Nomenclature of nucleic acids: . a. nucleosides*. . b. nucleotides. Structure . and function of . purines and pyrimidines. . Origin . of atoms in the purine . ring and in the pyrimidine ring.. nucleotides is essential for . life . processes. nucleotides . are the . activated precursors . of nucleic . acids. As such, they are necessary for the replication of the genome . an . adenine nucleotide, ATP, is . C483 Spring 2013. 1. A . ribose sugar is added to ________ rings after their synthesis and to ________ rings during their synthesis.. A) purine; pyrimidine. B) pyrimidine; purine. C) purine; purine. D) pyrimidine; pyrimidine. SIU-SOM. Pyrimidines. and Purines. Outline. Pyrimidine and purine . synthesis. Pyrimidine and purine salvage/degradation. Pathway disorders. Pyrimidine and Purine Synthesis. HCO. 3. -. + . Gln. CP. De Novo. Synthesis of . Purine. Nucleotides. We use for . purine. nucleotides the entire . glycine. molecule (atoms 4, 5,7), the amino nitrogen of . aspartate. (atom 1), amide nitrogen of glutamine (atoms 3, 9), components of the . Metabolism. Dr. Anissa Atif Mirza. Synopsis. Fates of dietary Nucleoproteins/Nucleic Acids.. De novo Biosynthesis of Purines and Pyrimidines.. Salvage of Purines and Pyrimidines. Catabolism of Purines and Pyrimidines. OBJECTIVES:. Nomenclature of nucleic acids: . a. nucleosides*. . b. nucleotides. Structure . and function of . purines and pyrimidines. . Origin . of atoms in the purine . ring and in the pyrimidine ring.. Components of DNA. Sugar = Deoxyribose. Ribose is missing hydroxyl group (-. OH. ) from 2’C. Phosphate = PO. 4. 3-. Links to the sugar @ either its 3’C or its 5’C. Water (H. OH. ) is lost in the condensation reaction. Dr. Anissa Atif Mirza. Synopsis. Fates of dietary Nucleoproteins/Nucleic Acids.. De novo Biosynthesis of Purines and Pyrimidines.. Salvage of Purines and Pyrimidines. Catabolism of Purines and Pyrimidines. Kumar. Nucleotide Metabolism. PURINE RIBONUCLEOTIDES: formed . de novo. i.e., purines are . not. initially synthesized as free bases. First purine derivative formed is Inosine Mono-phosphate (IMP). Chemistry of purines and pyrimidines. Nucleic Acid. Long chains of repeated nucleotides. A nucleotide consists of:. 1- Nitrogenous base. 2- Pentose sugar. 3- One or more phosphate groups. History. Nucleotide. Met.. Purine. Met.. Learning Objectives. 1. How . Are Purines Synthesized? . 2. . How Are Purines Catabolized?. 3. . How Are . Pyrimidines. Synthesized and . . . Catabolized. ?.  . 4. . How Are . Protein Synthesis. A histology technician studies the microscopic makeup of tissues, cells, and bodily fluids with the purpose of detecting and identifying the presence of a specific disease.. They determine blood types and the concentrations of drugs and other substances .