PDF-Feline Spongiform

. Other ruminant species cats non human primates and humans are occasionally affected this disease is called feline spongiform encephalopathy FSE in cats and variant Creutzfeldt Jakob disease vCJD in people BSE is a relatively new disease that was fir By Mr. . Melby. Adapted by Mr. Behrends. History. Also descendants of the . Miacis. The first ‘feline’ was the . Dictis. about 35 Million Years Ago. Cats were domesticated later than dogs. Potentially about 4000 years ago. Christina Hill . Department of Biological Sciences, York College of Pennsylvania. Project Summary. Bovine Spongiform Encephalopathy (BSE) and Natural Scrapie are prion diseases that result from the mis-folding of proteins in the brain. One mis-folded protein can cause other proteins to mis-fold creating florid plaques that can affect motor function and decrease lifespan. Prion diseases can be transferred to animal species that are not naturally susceptible to these diseases through gene transfer. Research shows that brain plaque isolates from animals infected with prion diseases can be collected and inserted into the brains of transgenic mice. In the proposed experiment, 10 (OvTgPrP4) transgenic mice will be injected with normal saline, 10 with BSE isolates and 10 with Natural Scrapie isolates. Inoculated transgenic mice are observed for changes in motor function each week for course of their lifespan. After expiration, the mice can be dissected and their brain removed. The removed brains would be paraffin-embedded for microtome sectioning. These sections will be stained using Immunohistochemistry to look for the presence of florid plaques associated with the respective disease. Isolates from each mouse brain will also be tested for infection using a Sandwich ELISA test. Infection in all mice inoculated with the respective diseases should be found, as well as a decrease in motor dysfunction and lifespan. Effective transmission of prion diseases to species without natural susceptibility can allow for more effective medical models to be developed and increased knowledge of these diseases.. Descended from . dog ancestor . Miacis. General timeline. First feline cat: ~. 35. million years ago. Modern cats: ~. 7. million years ago. Domestication: ~. 4,000. years . ago. History of Cats . When humans were predominantly hunters, dogs were of great use, and thus were domesticated long before cats. 26 26 26 26 6 6 6 CH CH CH H RO RO RO RO RO O N NI NI NI NI N C C C C C FE FE FE FE FE FE FE L LI LI LI LI I LI NE NE NE NE E E G G G G G G G IN IN IN IN I N GI GI G GI G I VO V VO V VO V O ST ST ST Symptoms: sneezing, nasal discharge, runny eyes, cough, oral or nasal ulcers, sniffles, fever, hoarse voice, or any combination thereof What Cats Are at Risk? Despite the highly contagious nature o (Credit Hours-3+1). Prions. diseases. Transmissible spongiform encephalopathies (TSEs). Infectious . amyloidosis. Unconventional slow virus degenerative . encephalopathies. Introduction. Prions. diseases/ TSE are a family of: . . Distribution of animal rabies in the United States, 1999. The percentages relate to the total number of cases of animal rabies. . Cats are not vaccinated in the US. . 1.1 4.3 0.9 0.6-----2008 . Piccardo P, Cervenakova L, Vasilyeva I, Yakovleva O, Bacik I, Cervenak J, et al. Candidate Cell Substrates, Vaccine Production, and Transmissible Spongiform Encephalopathies. Emerg Infect Dis. 2011;17(12):2262-2269. https://doi.org/10.3201/eid1712.110607. PATHOMORPHOLOGY II. UWM . 2019. INDEX. AETIOLOGICAL AGENT: CORONAVIRUS. FIPV. INFECTION. PATHOGENESIS. DEVELOPMENT OF ONE OF TWO FORMS OF FIP. NONEFFUSIVE FORM OR DRY FORM. CLINICAL SIGNS. PATHOMORPHOLOGICAL FINDINGS. UNIVERSITY OF WARMIA AND MAZURY, OLSZTYN. PATHOMORPHOLOGY . III. INDEX. INTRODUCTION. SYMPTOMS. MACROSCOPIC LESIONS. MICROSCOPIC LESIONS. TREATMENT. PREVENTION. BIBLIOGRAPHY. INTRODUCTION. Caused. 2. CNS Infection - Meninges. CNS infections: most are due to sepsis. Pathogenesis:. Hematogenous spread (most common) . Traumatic implantation . Local extension from nearby infection . Ascent of peripheral nerve. What is FIP?. Feline infectious peritonitis (FIP) is a clinical important disease of cats caused by a virulent biotype of feline coronavirus.. That disease occurs worldwide in wild and domestic cats.. Assist. Prof. Dr. Hussein Al . Naji. Bovine spongiform encephalopathy (BSE) is a progressive, fatal, infectious neurologic disease of cattle that resembles scrapie of sheep and goats. It was first diagnosed in the UK in 1986. Approximately 200,000 cases of BSE have been diagnosed in cattle, almost all of which were in the UK. In 1992, at the peak of the UK outbreak, 37,280 cases were reported in a single year..