Objectives Monoamines and Depressive States Genotype Endophenotype Phenotype Hypothesis Implications for Drug Design Focusing on Serotonin ReceptorSpecific Antidepressants Focusing on Serotonin ReceptorSpecific Antidepressants SARI and NASA ID: 677319
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Slide1
Matching Symptoms and Receptor-Binding Profiles in Depression: Focus on 5-HT ReceptorsSlide2Slide3
ObjectivesSlide4
Monoamines and Depressive StatesSlide5
Genotype, Endophenotype, Phenotype HypothesisSlide6
Implications for Drug DesignSlide7
Focusing on Serotonin Receptor-Specific AntidepressantsSlide8
Focusing on Serotonin Receptor-Specific Antidepressants: SARI and NASA Slide9Slide10
Focusing on Serotonin Receptor-Specific Antidepressants: SPARI and MSSRASlide11
Why Is This Important Theoretically?Slide12Slide13
5-HT ReceptorsSlide14
Applying This FrameworkSlide15
Vignette 1: 5-HT1A Receptor AgonismSlide16
Vignette 1Slide17
Vignette 2: 5-HT1B/D AntagonismSlide18
Vignette 2Slide19
Vignette 3: 5-HT3
AntagonismSlide20
Vignette 3Slide21
Vignette 4: 5-HT7
AntagonismSlide22
Vignette 4Slide23
In these examples of 4 patients, we have oversimplified in order to discuss 1 receptor at a timeSlide24
In How Many Ways Can 1 Drug Manipulate 5-HT?Slide25
ConclusionsSlide26
AbbreviationsSlide27
Abbreviations (cont)Slide28
ReferencesSlide29
References (cont)Slide30
References (cont)