Matching Symptoms and Receptor-Binding Profiles in Depression: Focus on 5-HT Receptors
Presentations text content in Matching Symptoms and Receptor-Binding Profiles in Depression: Focus on 5-HT Receptors
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Matching Symptoms and Receptor-Binding Profiles in Depression: Focus on 5-HT Receptors
Slide2Slide3Objectives
Slide4Monoamines and Depressive States
Slide5Genotype, Endophenotype, Phenotype Hypothesis
Slide6Implications for Drug Design
Slide7Focusing on Serotonin Receptor-Specific Antidepressants
Slide8Focusing on Serotonin Receptor-Specific Antidepressants: SARI and NASA
Slide9Slide10Focusing on Serotonin Receptor-Specific Antidepressants: SPARI and MSSRA
Slide11Why Is This Important Theoretically?
Slide12Slide135-HT Receptors
Slide14Applying This Framework
Slide15Vignette 1: 5-HT1A Receptor Agonism
Slide16Vignette 1
Slide17Vignette 2: 5-HT1B/D Antagonism
Slide18Vignette 2
Slide19Vignette 3: 5-HT3
Antagonism
Slide20Vignette 3
Slide21Vignette 4: 5-HT7
Antagonism
Slide22Vignette 4
Slide23In these examples of 4 patients, we have oversimplified in order to discuss 1 receptor at a time
Slide24In How Many Ways Can 1 Drug Manipulate 5-HT?
Slide25Conclusions
Slide26Abbreviations
Slide27Abbreviations (cont)
Slide28References
Slide29References (cont)
Slide30References (cont)
Slide31Slide32
Matching Symptoms and Receptor-Binding Profiles in Depression: Focus on 5-HT Receptors
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