Matching Symptoms and Receptor-Binding Profiles in Depression: Focus on 5-HT Receptors

Matching Symptoms and Receptor-Binding Profiles in Depression: Focus on 5-HT Receptors Matching Symptoms and Receptor-Binding Profiles in Depression: Focus on 5-HT Receptors - Start

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Matching Symptoms and Receptor-Binding Profiles in Depression: Focus on 5-HT Receptors - Description

Objectives. Monoamines and Depressive States. Genotype, Endophenotype, Phenotype Hypothesis. Implications for Drug Design. Focusing on Serotonin Receptor-Specific Antidepressants. Focusing on Serotonin Receptor-Specific Antidepressants: SARI and NASA . ID: 677319 Download Presentation

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Matching Symptoms and Receptor-Binding Profiles in Depression: Focus on 5-HT Receptors




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Presentations text content in Matching Symptoms and Receptor-Binding Profiles in Depression: Focus on 5-HT Receptors

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Matching Symptoms and Receptor-Binding Profiles in Depression: Focus on 5-HT Receptors

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Objectives

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Monoamines and Depressive States

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Genotype, Endophenotype, Phenotype Hypothesis

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Implications for Drug Design

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Focusing on Serotonin Receptor-Specific Antidepressants

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Focusing on Serotonin Receptor-Specific Antidepressants: SARI and NASA

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Focusing on Serotonin Receptor-Specific Antidepressants: SPARI and MSSRA

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Why Is This Important Theoretically?

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5-HT Receptors

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Applying This Framework

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Vignette 1: 5-HT1A Receptor Agonism

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Vignette 1

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Vignette 2: 5-HT1B/D Antagonism

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Vignette 2

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Vignette 3: 5-HT3

Antagonism

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Vignette 3

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Vignette 4: 5-HT7

Antagonism

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Vignette 4

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In these examples of 4 patients, we have oversimplified in order to discuss 1 receptor at a time

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In How Many Ways Can 1 Drug Manipulate 5-HT?

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Conclusions

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Abbreviations

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Abbreviations (cont)

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References

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References (cont)

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References (cont)

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