PPT-Matching Symptoms and Receptor-Binding Profiles in Depression: Focus on 5-HT Receptors

Objectives Monoamines and Depressive States Genotype Endophenotype Phenotype Hypothesis Implications for Drug Design Focusing on Serotonin ReceptorSpecific Antidepressants Focusing on Serotonin ReceptorSpecific Antidepressants SARI and NASA . . DR NARENDRA KUMAR. . Pharmacodynamics. is the study of the biochemical and physiological effects of drugs and their mechanisms of action. . Simply stated, . pharmacodynamics. refers to the effects of a drug on the body.. Perampanel. :. a selective non-competitive. AMPA receptor antagonist. Information prepared by Eisai Europe Ltd. 1. Mode of Action (MOA) of existing anti-epileptic drugs (AEDs) . Glutamate mediated Post Synaptic Excitation. A Selective Overview. Carl Rosow, M.D., Ph.D.. Disclosures. Consultant – Salix Pharmaceuticals. Topics for Today. Pharmacodynamics. Receptors, potency, efficacy. Agonists, antagonists. The dose response curve. Dr. SA . Ziai. Pharmacology. Pharmacology . can be defined as the study of substances that interact with living systems through chemical processes, especially by binding to regulatory molecules and activating or inhibiting normal body processes. . Receptor. A receptor is a protein molecule usually embedded within the cell membrane with part of its structure exposed on the outside of the cell.. The protein surface is a complicated shape containing hollows, ravines, and ridges.. Dr . Amena. . Rahim. Biochemistry. Biomedical Importance. Intercellular communication mechanisms are necessary requirements for this adaptation. . The nervous system and the endocrine system provide this intercellular, organism-wide communication. . :. a selective non-competitive. AMPA receptor antagonist. Information prepared by Eisai Europe Ltd. 1. Mode of Action (MOA) of existing anti-epileptic drugs (AEDs) . Glutamate mediated Post Synaptic Excitation. Evidence for Adenosine/Dopamine Receptor Interactions: Indications for Heteromerization Rafael Franco, Ph.D., Sergi Ferr GPCR FAMILY. CLASS A STRUCTURAL ANALYSIS. TASTE RECEPTORS. CONCLUSIONS & QUESTIONS. GPCRS. OVERVIEW . Also known as. 7TM receptors. Largest family of proteins in the human genome (Nearly 1000 such receptors are though to be present ). Learning Objectives. Learn the general structure and properties of hormones.. Know the differences between Hormones, Neurotransmitters & enzymes. 3. . Understand . the general properties of signaling molecules (ligands), cell-surface receptors, & intracellular signal transduction components.. GPCR STRUCTURE AND FUNCTION G-protein-coupled receptors (GPCRs) or seven transmembrane domain receptors (7TM) comprise the largest superfamily of proteins in the body. In 6 Figure 1: Diversity by cells of the immune system are specifically called "cytokines". The following arethe classical endocrine organs of humans:1. Thyroid glandThyroid gland located in the frontal portion of the neck, u By. Hala. . Aqeel. Shams. M.B.Ch.B. /MSc. Clinical pharmacology. . Pharmacodynamics . describes the actions of a . drug. on the body. . Most drugs exert their . effects, . by interacting with . receptors. . by . Dr.Vani. Gupta. Homeostasis. Homeostasis. - maintaining internal stability within an organism and returning to a particular stable state after a fluctuation..