PPT-Matching Symptoms and Receptor-Binding Profiles in Depression: Focus on 5-HT Receptors

Objectives Monoamines and Depressive States Genotype Endophenotype Phenotype Hypothesis Implications for Drug Design Focusing on Serotonin ReceptorSpecific Antidepressants Focusing on Serotonin ReceptorSpecific Antidepressants SARI and NASA . . DR NARENDRA KUMAR. . Pharmacodynamics. is the study of the biochemical and physiological effects of drugs and their mechanisms of action. . Simply stated, . pharmacodynamics. refers to the effects of a drug on the body.. A Selective Overview. Carl Rosow, M.D., Ph.D.. Disclosures. Consultant – Salix Pharmaceuticals. Topics for Today. Pharmacodynamics. Receptors, potency, efficacy. Agonists, antagonists. The dose response curve. Pharmacodynamics. Seyed. Ali . Ziai. Receptor. Pharmacologic antagonists. Macromolecular Nature of Drug Receptors. Regulatory proteins. Enzymes. Transport proteins . Structural proteins. . Receptor- Effector Coupling. Receptor. A receptor is a protein molecule usually embedded within the cell membrane with part of its structure exposed on the outside of the cell.. The protein surface is a complicated shape containing hollows, ravines, and ridges.. Cytokine Receptors. These are the receptors present on membrane of responsive . target cells by which cytokines binds to exert their biological effects.. Cytokine Receptors Fall Within Five Families. . Enzyme-linked . receptors. Nuclear receptors. Stochasticity. in . signalling. .. Enzyme-linked receptors. . signalling. through growth factors, hormones, cytokines. acting locally at very low concentrations (10. Kuby Immunology. , . 7e: Chapter 3. Essential Concepts – 1. A cellular signal is any event that instructs a cell to change its metabolic or proliferative state. Signals are usually generated by the binding of a ligand to a complementary cell-bound receptor. Dr . Amena. . Rahim. Biochemistry. Biomedical Importance. Intercellular communication mechanisms are necessary requirements for this adaptation. . The nervous system and the endocrine system provide this intercellular, organism-wide communication. . is. afferent neuron.. (b) Receptor . regulates. afferent neuron.. To CNS. Afferent. neuron. Afferent. neuron. To CNS. Receptor. protein. Sensory. receptor. Stimulus. Neurotransmitter. Sensory. receptor. :. a selective non-competitive. AMPA receptor antagonist. Information prepared by Eisai Europe Ltd. 1. Mode of Action (MOA) of existing anti-epileptic drugs (AEDs) . Glutamate mediated Post Synaptic Excitation. Y. Katsu; E-mail: ykatsu@sci.hokudai.ac.jp Abstract. The mineralocorticoid receptor (MR) is descended from a corticoid receptor (CR), which has descendants in lamprey and hagfish, cyclostomes (jawles by cells of the immune system are specifically called "cytokines". The following arethe classical endocrine organs of humans:1. Thyroid glandThyroid gland located in the frontal portion of the neck, u Dept. of Physiology. SKHMC. Definition. Sensory nerve endings that terminate in periphery as bare . unmyelinated ending. s. Capsulated structures. Biological transducers. Convert various forms of energy into action potentials. Timon Lwo (Honors Capstone). 2. , . Harkamal. Jhajj. 1,2. *, John Schardt. 1,3. , Emily Yao. 5. , Peter Tessier. 1,2,3,4. 1. Biointerface Institute, University of Michigan, Ann Arbor, MI. Department of .