PPT-Accelerating antibody discovery using transgenic animals overexpressing the neonatal Fc

Imre Kacskovics CEO amp CSO FcRn the immune response booster The neonatal Fc receptor FcRn FcRnIgG interaction FcRn mediates maternal IgG transport protect s IgG and albumin . (such as bacteria,. fungi, and viruses). INNATE IMMUNITY. (all animals). • Rapid response. Recognition of traits shared. by broad ranges of. pathogens, using a small. set of receptors. •. Recognition of traits . I. Selective Breeding. 1.) . Selective breeding . = The process by which desired traits of certain plants and animals are selected and passed on to their future generations.. Breed only those plants or animals with desirable traits. TRANSGENIC ANIMALS-. :. INTRODUCTION. OBJECTIVES OF GENE TRANSFER. VECTORS. Methods of modified . dna. insertion. Transgenic animals. INTRODUCTION. A TRANSGENIC ANIMAL CONTAINS IN ITS GENOME OR GENES INTRODUCED BY ONE OR THE OTHER TECHNIQUES OF TRANSFECTION. . Response occurs within days of the infection. . Highly specific. . Highly diverse. . Memory component. . Major cell types involved: T cells, B cells and antigen presenting cells. Antigens and Antibodies (CH4). Genetic manipulation strategies in environmental biotechnology Presented By : * shahzaib khan *WAQAR ALI Contents What is Environmental Biotechnology Genetic Manipulations strategies In Plants In Animals Applications of Genetic Engineering. Objectives. ____________________the usefulness of some transgenic organisms to humans.. Describe. Transgenic Organisms. An organism described . as_______________, . Biomedical Technology I. 3.03. GMO’s:. Also known as Transgenic Organisms. Are species that carry one or more genes from another species.. These have continued to improve since the 1970’s. Advantages:. 6. HAstrepII. -OsPti1a. OsPti1a. -. HAstrepII. OsPti1a. CBB. WB: anti-HA antibody. B. A. C. OsPti1a. -. HAstrepII. 18. 26. 4. 6. EV. ospti1a. WT. EV. HAstrepII. -OsPti1a. EV. ospti1a. WT. EV. Supplemental Figure 1. Complementation test of . Dr. Kamal Kumar Gupta. Mice from Dr. Ralph L. . Brinster's. Giant . M. ouse Experiment . T. he human . growth hormone gene was expressed in the liver of mice. Knockout Mouse. A . mouse in which a gene affecting hair growth has been knocked . KAMAL KUMAR GUPTA. Transgenic Animals. Dolly. What is a transgenic animal? . A transgenic animal is one whose genome has been changed to carry genes from other . species. transgenes are functionally expressed and stably inherited in the transgenic animals.. Applications. UNIT. TOPIC. FACULTY. Unit I. Microbial biotechnology . Genetic manipulation, Engineering microbes for the production of antibiotics, enzymes, insulin, growth hormones, monoclonal antibodies, microbes for clearing oil spills. Introduction. Examples of Transgenic Animals. Finite Cell Lines. 1. 3. Creating Transgenic Animals. 2. Few Questions????. What is a Transgenic Organism. ?. A transgenic organism is one which contains novel heritable genetic material. Timon Lwo (Honors Capstone). 2. , . Harkamal. Jhajj. 1,2. *, John Schardt. 1,3. , Emily Yao. 5. , Peter Tessier. 1,2,3,4. 1. Biointerface Institute, University of Michigan, Ann Arbor, MI. Department of . 50K. genotypes were used for haplotype discovery. Methods tested on . Brachyspina. .. Numbers of expected homozygous animals were calculated using real . matings. and ranged from . 7. to . 90. for .