PPT-Development of novel bi-clustering

algorithm and its application in single cell RNA seq data analysis and identification of gain or loss of functions of somatic mutations Chi Zhang PhD Center for Computational Biology and Bioinformatics. Brendan and Yifang . April . 21 . 2015. Pre-knowledge. We define a set A, and we find the element that minimizes the error. We can think of as a sample of . Where is the point in C closest to X. . Lecture outline. Distance/Similarity between data objects. Data objects as geometric data points. Clustering problems and algorithms . K-means. K-median. K-center. What is clustering?. A . grouping. of data objects such that the objects . New Jersey’s New & Improved Planning Tool. In a nutshell…. Conventional Development. “Large Lot Zoning”. Uniform Lot Sizes. Development covers most, or all, of the site. Contiguous Cluster Development. issue in . computing a representative simplicial complex. . Mapper does . not place any conditions on the clustering . algorithm. Thus . any domain-specific clustering algorithm can . be used.. We . What is clustering?. Why would we want to cluster?. How would you determine clusters?. How can you do this efficiently?. K-means Clustering. Strengths. Simple iterative method. User provides “K”. Unsupervised . learning. Seeks to organize data . into . “reasonable” . groups. Often based . on some similarity (or distance) measure defined over data . elements. Quantitative characterization may include. Lecture outline. Distance/Similarity between data objects. Data objects as geometric data points. Clustering problems and algorithms . K-means. K-median. K-center. What is clustering?. A . grouping. of data objects such that the objects . 1. Mark Stamp. K-Means for Malware Classification. Clustering Applications. 2. Chinmayee. . Annachhatre. Mark Stamp. Quest for the Holy . Grail. Holy Grail of malware research is to detect previously unseen malware. 1. Mark Stamp. K-Means for Malware Classification. Clustering Applications. 2. Chinmayee. . Annachhatre. Mark Stamp. Quest for the Holy . Grail. Holy Grail of malware research is to detect previously unseen malware. Produces a set of . nested clusters . organized as a hierarchical tree. Can be visualized as a . dendrogram. A . tree-like . diagram that records the sequences of merges or splits. Strengths of Hierarchical Clustering. Produces a set of . nested clusters . organized as a hierarchical tree. Can be visualized as a . dendrogram. A tree-like diagram that records the sequences of merges or splits. Strengths of Hierarchical Clustering. Log. 2. transformation. Row centering and normalization. Filtering. Log. 2. Transformation. Log. 2. -transformation makes sure that the noise is independent of the mean and similar differences have the same meaning along the dynamic range of the values.. Randomization tests. Cluster Validity . All clustering algorithms provided with a set of points output a clustering. How . to evaluate the “goodness” of the resulting clusters?. Tricky because . What is clustering?. Grouping set of documents into subsets or clusters.. The Goal of clustering algorithm is:. To create clusters that are coherent internally, but clearly different from each other.