PPT-Predicting the impact of mutations using pathway-guided integrative genomics

AACR Annual Meeting 2012 Major Symposium Designing Rational Combination Therapy for Cancer Josh Stuart UC Santa Cruz Apr 3 2012 Disclosure SAB for Five3 Genomics Overview of pathwayguided approach. Ben Kligler, M.D., Patricia Lebensohn, M.D., Sally Dodds, Ph.D., Raymond Teets, M.D., & Victoria Maizes, M.D.. Presentation Objectives. The objectives of this presentation are to:. Describe the function of formative evaluation for curriculum development.. order integrative therapeutics iti. integrative therapeutics iti. online integrative therapeutics iti. cheap integrative therapeutics iti. integrative therapeutics iti cost. iti integrative therapeutics. Anthroposophic Medicine as integrative . medicine. Madeleen. Winkler, . general. practitioner. Gouda, the . N. etherlands. Madeleen Winkler, ECIM congres 7,8 October 2011, Berlin. Integrative medicine in general practice . Jessica Hawley. Compiled . By: . C. Kohn, Waterford, WI. Objectives. Identify and analyze impacts of mutation.. Interpret impacts of mutation.. Analyze genetic information to determine mutations.. Work on SAE Record Books.. The value of an integrative leader Professional DEVELOPMENT Support request: LEADERSHIP PROGRAM IN INTEGRATIVE HEALTHCARE AT DUKE UNIVERSITY Your organization’s logo here Submitted by: YOUR NAME DATE Point mutations. single base change . silent mutation. no amino acid change. redundancy in code. missense. change amino acid. Changes the final protien. nonsense. change to stop codon. Stopping prematurely . Understand how they occur. Analyze the different types of mutations. Understand how mutations affect amino acid sequences and proteins. Objective. Central Dogma. DNA is transcribed into RNA, RNA is translated into proteins. Conditional mutations. Point mutations. In . point mutations . the sequence of the DNA has been altered at a single position. Where this change consists of replacing one nucleotide by another, it is known as a . Bo Xu, . Shengxian. Tu, Lei Song, . Zening. . Jin. , Bo Yu, . Guosheng. Fu, . Yujie. Zhou, . Jian’an. Wang, . Yundai. Chen, Jun Pu, . Lianglong. Chen, . Xinkai. Qu, . Junqing. Yang, . Xuebo. There are two basic types of mutations:. Gene mutations - mutations that produce changes in a single gene. Chromosomal mutations - mutations that produce changes in whole chromosomes. Gene mutations . JHI Partners Forum, 2012. Linda A. Lee, MD. Johns Hopkins Integrative Medicine & Digestive Center. Division of Gastroenterology and . Hepatology. Johns Hopkins Integrative Medicine & Digestive Center. mutation. Mutations. Actual Mutations . in fruit flies. What is a mutation?. A mutation is any change in a cell’s DNA. A mutation can occur in an individual gene. - results in a single changed protein. Integrative oncology is a patient-centered, evidence-informed field of cancer care that utilizes mind and body practices, natural products, and/or lifestyle modifications from different traditions alongside conventional cancer treatments. Integrative oncology aims to optimize health, quality of life, and clinical outcomes across the cancer care continuum and to empower people to prevent cancer and become active participants before, during, and beyond cancer treatment.. Ravi Madduri. madduri@anl.gov. Joint work with Paul . Davé. , Lukasz . Lacinski. , Alex Rodriguez, . Dinanath. . Sulakhe. , Ryan Chard and Ian Foster. Globus Genomics is developed, operated, and supported by researchers, developers, and .