PPT-Predicting the impact of mutations using pathway-guided integrative genomics

AACR Annual Meeting 2012 Major Symposium Designing Rational Combination Therapy for Cancer Josh Stuart UC Santa Cruz Apr 3 2012 Disclosure SAB for Five3 Genomics Overview of pathwayguided approach. Out-of-Class . Learning: . A Model for Partnerships. Betsy Barefoot. John Gardner. . Integrative Learning. An Important Avenue to Transforming What and How Students Learn. What Is Integrative Learning?. Miranda Wolpert. CORC Director. Plan. Advances in measuring outcomes- best approaches and measures. Effectiveness of services- using insights from CORC dataset. Thinking whole system- what CORC is doing to look at this. Jessica Hawley. Compiled . By: . C. Kohn, Waterford, WI. Objectives. Identify and analyze impacts of mutation.. Interpret impacts of mutation.. Analyze genetic information to determine mutations.. Work on SAE Record Books.. >2500 cancer genomes: Overall . functional . impact. Slides freely . downloadable . from . Lectures.GersteinLab.org. . & “tweetable” . (via . @. markgerstein. ). . See last slide . for more info.. Stirling Bryan, PhD. Graham Scotland, PhD. Mohsen Sadatsafavi, . PhD. Overview of session. Stirling Bryan:. In Search of Efficiency, Consistency, Fairness, and Impact in . HTA. Graham Scotland. Modelling screening and treatment pathways for diabetic retinopathy. East Los Angeles College . What. are Guided Pathways?. The 2017-18 California State Budget has provided $150 million in one-time grants to seed the expansion of the Guided Pathways framework across the California Community Colleges over the next five years. . Detection. Luis A. Diaz, M.D.. Johns Hopkins. Mutations are highly specific. Cancer Cell. Normal Cells. Pre-Cancer Cell. Mutations. No Mutations. Access to Somatic Mutations. Tumor Tissue. FFPE. Frozen tissue. Point mutations. single base change . silent mutation. no amino acid change. redundancy in code. missense. change amino acid. Changes the final protien. nonsense. change to stop codon. Stopping prematurely . Overview and Capabilities: . . High Throughput Sequencing Facility (HTSG). Functional Genomics M. ammalian Genotyping Core (MGC). Corbin Jones. Faculty Director. Piotr . Meiczkowski . Technologies . Beyond the Genome 2012. Informatics Workshop, Sep 27, 2012. Josh Stuart, UC Santa . Cruz. “It . is entirely in line with the accidental nature of mutations that . … . the vast . majority [are] . detrimental. What is Structural Genomics ?. Is the process of high-. throughtput. determination of 3-D structures of Biological macromolecules. What is the Goal of Structural Genomics ?. Provision of enough structural templates to facilitate homology modeling of most proteins.. Functional Applications of Human Genetics and Genomics Commissioned by the American Society of Human Genetics Produced by TEConomy Partners, LLC. Report Authors: Simon Tripp and Martin Grueber May 2 Chromatic modifying genes. Supplementary Figure 1. . Oncoprint. depicting the genomic landscape of MIBC from the TCGA cohort with co-occurring alterations in canonical pathways and cellular functions. Ravi Madduri. madduri@anl.gov. Joint work with Paul . Davé. , Lukasz . Lacinski. , Alex Rodriguez, . Dinanath. . Sulakhe. , Ryan Chard and Ian Foster. Globus Genomics is developed, operated, and supported by researchers, developers, and .