PPT-GLYCOGEN METABOLISM

GLYCOGEN Found in liver and skeletal muscles Represents 10 of weight of liver and 12 of muscles Stored in large cytosolic granules Elementary particles β particles consist of 50000 glucose residues. Understanding:. Metabolic pathways consist of chains and cycles of enzyme-catalysed reactions. Enzymes lower the activation energy of the chemical reactions that they catalyse. Enzyme inhibitors can be competitive or non-competitive. A. Metabolism. 1. Anabolism. A) synthesis reactions (building up). 2. Catabolism. A) lysis reactions (breaking down). B. Enzymes. 1. proteins that facilitate chemical reactions. Microbial Metabolism. METABOLISM OR BIOTRANSFORMATION . The conversion from one chemical form of a substance to another. . The term metabolism is commonly used probably because products of drug transformation are called . Pratt and . Cornely. Chapter 19. Regulation by Compartmentalization. Form of reciprocal regulation. Degradation vs biosynthesis. Requires transporters. Specialization of organs. Fuel Storage. Fuel Usage: About 7000 kJ/day minimum. Dr Anissa Atif Mirza. What is Metabolism?. Metabolism is a . network of metabolic /biochemical reactions.. Carried out in living cells.. In a. well organized, integrated and regulated manner.. Related to various biomolecules viz. Metabolism. Section 8.1: . Glycolysis. Section 8.2: . Gluconeogenesis. Section 8.3: . The Pentose Phosphate Pathway. Section 8.4:. . Metabolism of Other Important Sugars. Section 8.5:. . Glycogen Metabolism. Integration of Metabolism. Sugar metabolism. Lipid metabolism. Amino acid metabolism. Amino acid metabolism. Nucleotide metabolism. 0. 2. 4H. . 4e- . a . 2H. 2. 0. Oxygen is the ultimate destination for electrons in respiration. Integration Of Metabolism Metabolism Consist of Highly Interconnected Pathways The basic strategy of catabolic metabolism is to form ATP, NADPH , and building blocks for biosyntheses. 1. ATP is the universal currency of energy Insulin Signaling and Glycogen Synthesis. Glycogen. Primary energy storage carbohydrate in animals. Primary backbone has . a. 1 .  4 linkages and secondary . a. 1 6 linkages. Creates many ends of the molecule allowing for the fast release of glucose for energy conversion. Dr. Elio Quesada Gonzalez. Consultant Pediatrician. PRESENTATION OUTLINE. DEFINATION. EPIDEMIOLOGY. HISTORICAL PERSPECTIVE. CLASSIFICATION. TYPES. CLINICAL PRESENTATION. INVESTIGATION. MANAGEMENT.. DEFINATION. FATE OF . PYRUVATE. MADE FROM GLYCOLYSIS. FATE OF . PYRUVATE. MADE FROM GLYCOLYSIS. Lactic . acid fermentation occurs in muscle cells when oxygen is in low . supply.. Human Lactate . dehydrogenase . 1 Metabolism of Carbohydrates Diseases Associated with Glycogen Degradation Paper : 04 Metabolism of carbohydrates Module : 28 Diseases Associated with Glycogen Degradation Dr. Ramesh Kothari, &. The Pentose Phosphate Pathway. Dr. . Shaimaa. . Munther. . Glycogen Metabolism. A constant source of blood glucose is an absolute requirement for human life. Glucose is the greatly preferred energy source for the brain, and the required energy source for RBC and muscle, since it’s the substrate for anaerobic . Glycogen storage diseases (GSDs) occur when a defective enzyme is involved in a pathway for glycogen storage or degradation.. A micrograph shows an excess of stored glycogen (blue) in a liver biopsy of a patient with Cori’s disease..