PPT-Gene Regulation Part III

Mechanism of regulation of gene expression An overview Gene activity is controlled first and foremost at the level of transcription Much of this control is achieved through the interplay between proteins that bind to specific DNA sequences and their DNA binding sites . of gene expression. . References:. . Stryer. : “Biochemistry”, 5. th. Ed.. Hames. & Hooper: “Instant Notes in Biochemistry”, 2. nd. Ed.. 1. Basic principles of gene control. What is gene expression?. Eukaryotic Gene Regulation. How are genes turned on & off . in eukaryotes?. How do cells with the same genes differentiate to perform completely different, specialized functions?. Evolution of gene regulation. Gene Expression Group. 7/14/11. 2011 National Academies Northstar Institute for Undergraduate Education in Biology . Outline. Context. Review: Clicker Questions. Cell Differences (Think-Pair-Share). Regulation of Gene Expression (Mini-Lecture). Pre-transcriptional regulation. chromatin compaction . eg. . deacetylation. , . methylation. transcriptional initiation . ie. transcription factors to activate or repress. alternative promoters =. Outline. Objective. Mechanism. K. inase cascades and Phosphorylation/. dephosphorylation. . General. Learning/LTP. Synaptic strengthening. Control of gene expression. Transcription factors. Epigenetics. Using Probabilistic Graphical Models. Jianlin Cheng, PhD. University of Missouri. 2009. Bayesian Network Software. http://www.cs.ubc.ca/~murphyk/Software/BNT/bnsoft.html. Demo. Research in molecular biology is . CSCOPE. Unit: 08 Lesson: 01. There are hundreds of different types of cells in your body, and each type has a unique function. We’re going to compare some different types of cells to see how much they have in common. . Draw 8 boxes on your paper. Gene regulation accounts for some of the phenotypic differences between organisms with similar genes.. 2005-2006. Gene regulation in bacteria. Control of gene expression enables individual bacteria to adjust their metabolism to environmental change. The cerebellum is the region of the brain that coordinates motor control, and many human neural disorders impact the cerebellum.. Several spontaneous mouse mutants with motor defects have been found, including:. . Inter-locus Interactions. PBG 430. Locus. A. Allele A. Allele a. Locus. B. Allele B. Allele b. Phenotype. Inter-locus interactions . (Epistasis). Interaction(s) between alleles at different loci (i.e. interaction between genes). Gene Regulation Gene expression can be turned on, turned off, turned up or turned down! For example, as test time approaches, some of you may note that stomach acid production increases dramatically&# (Chapter 9). Presented by Dr. Laurie M. Erickson. Chair of the Department of Health Sciences. Blitstein Institute of Hebrew Theological College. Chicago, IL, USA.. Gene Expression can be Regulated.. Gene expression: . Definition:. Anything genetic above and beyond the . sequence. of nucleotides. Importance:. Everything. , especially development and genetic. responses to the environment.. Examples of Epigenesis:. 1) Development: tissue differentiation and timing. AP Bio – Ch. 16-21. Unit 6 – Overview. Ch. 16 – The Molecular Basis of Inheritance (DNA). Ch. 17 – Gene Expression: From Gene to Protein. Ch. 18 – Regulation of Gene Expression. Ch. . 19 . – .