PPT-Overview of BRCA1 and

BRCA2 What we know so far Dr Helen Hanson and Dr Katie Snape Joint Lead Consultants for Cancer Genetics Southwest Thames Regional Genetics Service St Georges Hospital London What are the . Omics. Data Analysis to Drug Treatments. Naruemon. . Pratanwanich. (. Ploy. ). and Pietro . Lio. ’. 28 . Oct . 2014. Outline. Introduction:. Why pathway-based analysis ?. Current tool. Our approach. cancers. Deborah Thompson. Centre for Cancer Genetic Epidemiology. The . 15 . Most Common Cancers, . UK 2011 (Cancer Research UK). Fam. RR. ~2. 2-3. ~2. 3-4. The 20 Most Common Cancers, . UK 2011 (Cancer Research UK). James Ford, MD and Nicki Chun, . MS, . LCGC. Cancer . Genetics Clinic. Stanford Cancer . Center. November 5, 2015. Breast/ Ovarian Cancer Syndrome. . Breast cancer diagnosed in 1/8- 1/0 women in US. Kristin . DePrince. Mattie, M.S.. Licensed / Certified Genetic Counselor. William G. Rohrer Cancer Genetics Program. Objectives. Describe . current approaches to genetic testing for hereditary cancer syndromes. Susan M. Domchek, MD. Basser Professor of Oncology. University of Pennsylvania . Sex. Age. Family . history. Depends on specific of family history. Depends on whether there is a k. nown . genetic . susceptibility. Generosa. . Grana. , MD. Professor, Cooper Medical School of Rowan University. Director, MD Anderson Cancer Center at Cooper. Overview. Factors that affect breast cancer risk. Tools to assess risk. Role of genetics in this process. . Inheritance. . Review. . Incomplete. . Inheritance. Co-dominance. . Inheritance. SBI3U. •. . When. . one. . (1). . allele. . is. . stronger. . (so. . dominant). . than. . the. . Alison J Whelan M.D., FACP. Professor of Medicine and Pediatrics. Director of the Hereditary Cancer Clinic. Washington University School of Medicine. Overview of today’s talk. Genetic testing. Genomic testing. Triple Negative Breast Cancer. Steven J. Isakoff, MD, PhD. Dana-Farber . Harvard Cancer . Center/ Massachusetts General Hospital Cancer . Center. August 19, 2017. sisakoff@partners.org. 46 year-old premenopausal woman . BRCA1 and BRCA2. Jennifer . Hardee. Normal function of the genes. BRCA1 & BRCA2 are in the same DNA repair pathway. Despite names, do not share any protein structure. Both are . tumor suppressors . ........................... ..... .. ..............- ........ ... .. . ....... .... ... . ....... .... .... ..... R E S .. ........ A Strong Candidate for the Breast and Ov . . cancer . development and treatment. Katsunori . Sugimoto. . nori.sugimoto. @rutgers.edu. Cancer . Abnormalities in . Proliferation . Contact inhibition. Energy . efficiency . glycolysis but not on TCA cycle. and the . Environment. Note: You will need to provide water and paper towels for participants.. Breast . Cancer Risk: . Genes . and the Environment. . Please complete the “Participant Card”. 3. Laura Cortesi. BRCA1/2 Mutations: Cancer Risks. BRCA1. BRCA2. Breast cancer to age 80. 50-85%. 50-85%. Ovarian cancer to age 80. 20-60%. up to 27%. Male . breast. . cancer. . Slight incr. . ~6%. Prostate cancer.