Have you Returned a completed consent form Signed your form Completed the online questionnaire Posted your blog entry If not DO IT TODAY Lecture 1 What is Genetics Genetics Pedagogies Project ID: 926668
Download Presentation The PPT/PDF document "Genetics pedagogies project" is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
Slide1
Genetics pedagogies project
Have you:
Returned a completed consent form?
Signed your form?
Completed the online questionnaire?
Posted your blog entry?
If not – DO IT TODAY!!!!
Slide2Lecture 1: What is Genetics?
Genetics Pedagogies Project
Annie Jamieson (A.K.Jamieson@leeds.ac.uk)
Slide3Inheritance as we observe it
Slide4Inheritance and development
Slide5Organism and environment
Slide6Source: Wikimedia Commons
Genes, environment and the honey bee
Queen and workers are genetically identical
Larvae fed initially on royal jelly then switched to pollen = sterile workers
Larvae fed exclusively on royal jelly = fertile queens
Slide7Genes, environment and fat mice
ob gene in mice encodes
leptin
, a hormone which regulates appetite and energy expenditure
Mice with mutant ob become morbidly obese
Slide8Jacapo
Werther
: Wikimedia Commons
Internal environment: Congenital anomalies
Affect approx. 1 in 33 babies (WHO)
50% due to genetic/environment/infectious factors
50% have no identified specific cause
Slide9Factors in congenital anomalies
Infections: e.g. rubella
Chemicals: pesticides, heavy metals (lead, mercury etc)
Radiation
Medicines: thalidomide; retinoic acid (acne medications)
Recreational drugs
Alcohol
Smoking
Maternal nutrition: folic acid; iodine
Slide10Human egg shortly after fertilization. Parental pro-nuclei are about to fuse.
Internal environment
Slide11Drosophila egg before fertilisation
Bicoid
protein directs head/thorax (anterior) development
Oskar
protein directs abdominal (posterior) development
Gurken
protein defines
dorso
-ventral axis
Slide12Terminology
Phenotype
GenotypeHaploid/diploidGene
Genome
Locus
Allele
Homozygous/ heterozygous
Slide13Source: Wikimedia Commons. Creator:
InvictaHOG
Slide14Human
karyotype
Source: http://www.genome.gov/glossary/resources/karyotype.pdf
Slide15Slide16Locus
Homozygote
for
1
Heterozygote
Homozygote
for
2
Allele 2
Allele1
Allele 2
Slide17Phenotype
Genotype
Blood
group
A
AA or AO
Blood group B
BB or BO
Blood group AB
AB
Blood group O
OO
A allele = A antigens
B allele = B antigens
O allele =non-functioning protein = no antigens
Slide18High cholesterol
High triglycerides
Genes
Age
Activity
Ethnicity
Sex
Smoking
Obesity
Alcohol
Diet
Blood
pressure
Diabetes
Cardiovascular disease
Stress/ class