PPT-Diuretics

A Kidney functions Kidneys have a number of essential functions 1 excretion 2 regulate fluid balance electrolyte composition acidbase balance 3 secrete enzyme renin 4 secrete erythropoietin a hormone that stimulates RBC. Brogan Spencer and Laura . Smitherman. What is a diuretic? . Substance . that promotes the formation (excretion) of urine. Name 3 common and important diuretics. Loop diuretics. Thiazide diuretics. Potassium sparing diuretics (action at . Drugs. Diuretics. A chemical agent that increases the rate of urine formation.. Reabsorption of Na in the kidney results in the reabsorption of water. It follows that inhibition of Na reabsorption will result in diuresis. Because of this, the term diuretic has come . furosmide. Made by . Zainab. . Albar. Supervised by . Dr.Ahmad. Shaker. Types of diuretics. Loop diuretics . ( furosemide , . Bumetanide. , . Torasemide. and . Ethacrynic. acid ).. Thiazide. . David W . Kabel. MD FACC. CHF-. Neurohormonal. Activation. NH activation is an acute adaptation that initially allows BP and cardiac output to be maintained. NH activation rapidly becomes detrimental. Learning Objectives. Classify. . the diuretic agents. Describe. . the mechanism of diuretic agents. Demonstrate. the pharmacological effects of typical diuretic agents. Propose. the rational clinical application . . Drugs affecting myometrium. . . Diuretics. . may. . be. . represented. . by. . the. . following. . groups. .. I. . Diuretics. . have. . a. . direct. . effect. . on. . the. . function. Most . diuretics also increase urinary excretion of solutes, especially sodium and . chloride. Most . diuretics that are used clinically act by decreasing the rate of sodium reabsorption from the . tubules . By the end of this class students will be able to:. Describe the mechanisms of renal ion and water reabsorption that are most relevant to diuretic action. Name the major diuretics used in clinical medicine. . System. . . Presented by:-. . . . . Dr.Archana. Assistant . Professor_cum_Jr.Scientist. Carbonic anhydrase is in the PCT, where it catalyzes the dehydration of H. 2. CO. 3. .. By blocking carbonic anhydrase, drugs block NaHCO3 reabsorption and cause diuresis.. Carbonic anhydrase inhibitors are now rarely used as diuretics. Ph.D. ). Department of Pharmacology and Therapeutics, . Afe. . Babalola. University,. Ado-. Ekiti. , . Ekiti. state.. Overview of renal functions. R. egulation . of water and electrolyte balances . Assistant. . lec. . . Shaymaa. Hasan Abbas. Diuretics. . Thiazides and related diuretics. - . Thiazides. and related compounds . are moderately potent diuretics; they inhibit sodium . reabsorption. HEART FAILURE, ANTIARRHYTHMICS . Ischaemic. . Heart. . Disease. . Cardiomyopathy. Arterial. . hypertension. Severe . dysrrhytmias. myocarditis. Acute. . Coronary. . Syndroma. (AIM…). . pulmonary. M.B.Ch.B/ MSc. Clinical pharmacology. Potassium-sparing diuretics . act in the collecting tubule to . inhibit. . Na + reabsorption and K+ excretion. . . Potassium. . levels must be monitored in patients treated with potassium-sparing diuretics. .