PPT-Diuretics A diuretic is a substance that increases the rate of urine volume output

Most diuretics also increase urinary excretion of solutes especially sodium and chloride Most diuretics that are used clinically act by decreasing the rate of sodium reabsorption from the tubules . Drugs. Diuretics. A chemical agent that increases the rate of urine formation.. Reabsorption of Na in the kidney results in the reabsorption of water. It follows that inhibition of Na reabsorption will result in diuresis. Because of this, the term diuretic has come . furosmide. Made by . Zainab. . Albar. Supervised by . Dr.Ahmad. Shaker. Types of diuretics. Loop diuretics . ( furosemide , . Bumetanide. , . Torasemide. and . Ethacrynic. acid ).. Thiazide. . A. Kidney functions. Kidneys have a number of essential functions:. 1. excretion. 2. regulate: . fluid balance . electrolyte composition . acid-base balance . 3. secrete enzyme renin . . 4. secrete erythropoietin (a hormone that stimulates RBC. Learning Objectives. Classify. . the diuretic agents. Describe. . the mechanism of diuretic agents. Demonstrate. the pharmacological effects of typical diuretic agents. Propose. the rational clinical application . Pathophysiology & Cases Discussion. Bambang. Budi . Siswanto. Prof MD, PhD, FIHA, . FAsCC. , FAPSC, FESC, FACC, FSCAI. Dept. Cardiology and Vascular Medicine University Indonesia. Medical Research Unit & Medical Education Unit & Coordinator Collaboration FKUI. and Diet. Vivek Bhalla, MD. Division of Nephrology. Stanford University School of Medicine. September . 14th, 2015. Anatomy of the Renal Block. Physiology. Pathophysiology. Urology. Body. Fluids -1. . Drugs affecting myometrium. . . Diuretics. . may. . be. . represented. . by. . the. . following. . groups. .. I. . Diuretics. . have. . a. . direct. . effect. . on. . the. . function. Dr. Pran Kishore Deb & Dr. . Bilal Al-. jaidi. Assistant Professor, Pharmaceutical Medicinal Chemistry. Faculty of Pharmacy, Philadelphia University-Jordan. Email: . pdeb@Philadelphia.edu.jo. . Diuretics. By the end of this class students will be able to:. Describe the mechanisms of renal ion and water reabsorption that are most relevant to diuretic action. Name the major diuretics used in clinical medicine. . Alwali. Assistant Professor in Pharmacology. College of Pharmacy-Al-. Nahrain. University. 1/3/2018. 1. Diuretics. are drugs that . increase the volume of urine excreted. . . Most diuretic . agents are . . Most diuretic agents are inhibitors of renal ion transporters that decrease the . reabsorption. of Na+ at different sites in the . nephron. . . As a result, Na+ and other ions, such as . Cl. −, enter the urine in greater than normal amounts along with water, which is carried passively to maintain osmotic equilibrium.. Carbonic anhydrase is in the PCT, where it catalyzes the dehydration of H. 2. CO. 3. .. By blocking carbonic anhydrase, drugs block NaHCO3 reabsorption and cause diuresis.. Carbonic anhydrase inhibitors are now rarely used as diuretics. diuresis. ). and sodium excretion (. natriuresis. ). RENAL TRANSPORT MECHANISMS . The kidney filters plasma water and solutes at the . glomerulus. at a very high rate (180 L/day) and must recover a significant percentage of most of these substances before excretion in the urine.. Eric Klug. Fluid Overload. Congestion is a primary cause of worsening heart failure and HF hospitalisation. Residual congestion at the time of discharge is a strong predictor of poor clinical outcomes and hospital readmission.