PPT-DIURETICS

Dr Pran Kishore Deb amp Dr Bilal Al jaidi Assistant Professor Pharmaceutical Medicinal Chemistry Faculty of Pharmacy Philadelphia UniversityJordan Email pdebPhiladelphiaedujo Diuretics. Brogan Spencer and Laura . Smitherman. What is a diuretic? . Substance . that promotes the formation (excretion) of urine. Name 3 common and important diuretics. Loop diuretics. Thiazide diuretics. Potassium sparing diuretics (action at . A. Kidney functions. Kidneys have a number of essential functions:. 1. excretion. 2. regulate: . fluid balance . electrolyte composition . acid-base balance . 3. secrete enzyme renin . . 4. secrete erythropoietin (a hormone that stimulates RBC. The obvious but sometimes not so obvious root cause . Dr Ivy Branin, ND. Simplicity Health Associates. Learning Objectives. Which commonly prescribed medications deplete nutrients? . What are the nutrient depletions associated with these medications?. . Drugs affecting myometrium. . . Diuretics. . may. . be. . represented. . by. . the. . following. . groups. .. I. . Diuretics. . have. . a. . direct. . effect. . on. . the. . function. Most . diuretics also increase urinary excretion of solutes, especially sodium and . chloride. Most . diuretics that are used clinically act by decreasing the rate of sodium reabsorption from the . tubules . . Care and Handling of Medications and Solutions. Medication Identification:. Medications come in a variety of packaging. Glass, Metal, and Plastic. Common Types of Containers in the OR:. Ampule Tubes . Substances that inhibit water excretion without affecting salt excretion. . . Reduce urine output . .. . More precise term . anti-. aquaretics. . Primary indication - diabetes . insipidus. Drug classification. Background. Primary effect of diuretics is to increase solute excretion, mainly as NaCl. Certain disease states may cause blood volume to increase outside of narrowly defined limits. Hypertension. Congestive heart failure. . System. . . Presented by:-. . . . . Dr.Archana. Assistant . Professor_cum_Jr.Scientist. . Most diuretic agents are inhibitors of renal ion transporters that decrease the . reabsorption. of Na+ at different sites in the . nephron. . . As a result, Na+ and other ions, such as . Cl. −, enter the urine in greater than normal amounts along with water, which is carried passively to maintain osmotic equilibrium.. Carbonic anhydrase is in the PCT, where it catalyzes the dehydration of H. 2. CO. 3. .. By blocking carbonic anhydrase, drugs block NaHCO3 reabsorption and cause diuresis.. Carbonic anhydrase inhibitors are now rarely used as diuretics. Ph.D. ). Department of Pharmacology and Therapeutics, . Afe. . Babalola. University,. Ado-. Ekiti. , . Ekiti. state.. Overview of renal functions. R. egulation . of water and electrolyte balances . diuresis. ). and sodium excretion (. natriuresis. ). RENAL TRANSPORT MECHANISMS . The kidney filters plasma water and solutes at the . glomerulus. at a very high rate (180 L/day) and must recover a significant percentage of most of these substances before excretion in the urine.. M.B.Ch.B/ MSc. Clinical pharmacology. Potassium-sparing diuretics . act in the collecting tubule to . inhibit. . Na + reabsorption and K+ excretion. . . Potassium. . levels must be monitored in patients treated with potassium-sparing diuretics. .