PPT-Anti-diuretics What are Anti-diuretics?

Substances that inhibit water excretion without affecting salt excretion Reduce urine output More precise term anti aquaretics Primary indication diabetes insipidus Drug classification. Brogan Spencer and Laura . Smitherman. What is a diuretic? . Substance . that promotes the formation (excretion) of urine. Name 3 common and important diuretics. Loop diuretics. Thiazide diuretics. Potassium sparing diuretics (action at . furosmide. Made by . Zainab. . Albar. Supervised by . Dr.Ahmad. Shaker. Types of diuretics. Loop diuretics . ( furosemide , . Bumetanide. , . Torasemide. and . Ethacrynic. acid ).. Thiazide. . A. Kidney functions. Kidneys have a number of essential functions:. 1. excretion. 2. regulate: . fluid balance . electrolyte composition . acid-base balance . 3. secrete enzyme renin . . 4. secrete erythropoietin (a hormone that stimulates RBC. 205b. Neuromuscular Blocking Agents (NMBAs). Cause skeletal muscle weakness or paralysis for purpose of preventing movement. Neuromuscular Blocking Agents (NMBAs). Cause skeletal muscle weakness or paralysis for purpose of preventing movement. and Diet. Vivek Bhalla, MD. Division of Nephrology. Stanford University School of Medicine. September . 14th, 2015. Anatomy of the Renal Block. Physiology. Pathophysiology. Urology. Body. Fluids -1. Dr. Pran Kishore Deb & Dr. . Bilal Al-. jaidi. Assistant Professor, Pharmaceutical Medicinal Chemistry. Faculty of Pharmacy, Philadelphia University-Jordan. Email: . pdeb@Philadelphia.edu.jo. . Diuretics. Most . diuretics also increase urinary excretion of solutes, especially sodium and . chloride. Most . diuretics that are used clinically act by decreasing the rate of sodium reabsorption from the . tubules . Background. Primary effect of diuretics is to increase solute excretion, mainly as NaCl. Certain disease states may cause blood volume to increase outside of narrowly defined limits. Hypertension. Congestive heart failure. By the end of this class students will be able to:. Describe the mechanisms of renal ion and water reabsorption that are most relevant to diuretic action. Name the major diuretics used in clinical medicine. . Alwali. Assistant Professor in Pharmacology. College of Pharmacy-Al-. Nahrain. University. 1/3/2018. 1. Diuretics. are drugs that . increase the volume of urine excreted. . . Most diuretic . agents are . . Most diuretic agents are inhibitors of renal ion transporters that decrease the . reabsorption. of Na+ at different sites in the . nephron. . . As a result, Na+ and other ions, such as . Cl. −, enter the urine in greater than normal amounts along with water, which is carried passively to maintain osmotic equilibrium.. Diuretics. Sympathoplegic agents. Direct vasodilators. Agents that block action of angiotensin. Most anti-HT drugs ↓ BP by ↓ CO &/or ↓ PVR. Mechanisms for Controlling Blood Pressure (BP):. Mild HT can be controlled with a single drug;. . Aqeel. Shams. M.B.Ch.B. /MSc. Clinical pharmacology. . Hypertension . is defined as a sustained systolic blood pressure of 140 mm Hg or higher or a sustained diastolic blood pressure of 90 mm Hg or higher. . diuresis. ). and sodium excretion (. natriuresis. ). RENAL TRANSPORT MECHANISMS . The kidney filters plasma water and solutes at the . glomerulus. at a very high rate (180 L/day) and must recover a significant percentage of most of these substances before excretion in the urine..