PPT-Diuretics

Drugs affecting myometrium Diuretics may be represented by the following groups I Diuretics have a direct effect on the function. 41. Diuretics. Anatomy and Physiology. Anatomy. Basic functional unit of the kidney: nephron. Four functionally distinct regions. Glomerulus. Proximal convoluted tubule. Loop of Henle. Distal convoluted tubule. furosmide. Made by . Zainab. . Albar. Supervised by . Dr.Ahmad. Shaker. Types of diuretics. Loop diuretics . ( furosemide , . Bumetanide. , . Torasemide. and . Ethacrynic. acid ).. Thiazide. . A. Kidney functions. Kidneys have a number of essential functions:. 1. excretion. 2. regulate: . fluid balance . electrolyte composition . acid-base balance . 3. secrete enzyme renin . . 4. secrete erythropoietin (a hormone that stimulates RBC. 205b. Neuromuscular Blocking Agents (NMBAs). Cause skeletal muscle weakness or paralysis for purpose of preventing movement. Neuromuscular Blocking Agents (NMBAs). Cause skeletal muscle weakness or paralysis for purpose of preventing movement. Dr. Pran Kishore Deb & Dr. . Bilal Al-. jaidi. Assistant Professor, Pharmaceutical Medicinal Chemistry. Faculty of Pharmacy, Philadelphia University-Jordan. Email: . pdeb@Philadelphia.edu.jo. . Diuretics. 15.03.2020. 1. LO: please insert relevant Learning objective reference here. 2. DIURETICS. 3. Learning Objectives for Diuretics. Renal physiology:. explain the physiology of the renal system and. how drugs impact ionic composition. By the end of this class students will be able to:. Describe the mechanisms of renal ion and water reabsorption that are most relevant to diuretic action. Name the major diuretics used in clinical medicine. . System. . . Presented by:-. . . . . Dr.Archana. Assistant . Professor_cum_Jr.Scientist. . Most diuretic agents are inhibitors of renal ion transporters that decrease the . reabsorption. of Na+ at different sites in the . nephron. . . As a result, Na+ and other ions, such as . Cl. −, enter the urine in greater than normal amounts along with water, which is carried passively to maintain osmotic equilibrium.. Carbonic anhydrase is in the PCT, where it catalyzes the dehydration of H. 2. CO. 3. .. By blocking carbonic anhydrase, drugs block NaHCO3 reabsorption and cause diuresis.. Carbonic anhydrase inhibitors are now rarely used as diuretics. Assistant. . lec. . . Shaymaa. Hasan Abbas. Diuretics. . Thiazides and related diuretics. - . Thiazides. and related compounds . are moderately potent diuretics; they inhibit sodium . reabsorption. diuresis. ). and sodium excretion (. natriuresis. ). RENAL TRANSPORT MECHANISMS . The kidney filters plasma water and solutes at the . glomerulus. at a very high rate (180 L/day) and must recover a significant percentage of most of these substances before excretion in the urine.. HEART FAILURE, ANTIARRHYTHMICS . Ischaemic. . Heart. . Disease. . Cardiomyopathy. Arterial. . hypertension. Severe . dysrrhytmias. myocarditis. Acute. . Coronary. . Syndroma. (AIM…). . pulmonary. M.B.Ch.B/ MSc. Clinical pharmacology. Potassium-sparing diuretics . act in the collecting tubule to . inhibit. . Na + reabsorption and K+ excretion. . . Potassium. . levels must be monitored in patients treated with potassium-sparing diuretics. .