PPT-Quantifying contributions of mutations and homologous reco

genomic diversity Sergei Maslov Department of Biosciences Brookhaven National Laboratory New York Bacterial genome evolution happens in cooperation with phages Variation between E coli strains. 1 and 1722A 1 et seq Unlimited Unlimi ted Unlimited 500candidateelection aj Unlimited Alaska 57511 1513065 to 080 500candidateyear Aggregate amounts candidates may accept from nonresidents 20000yeargub candidate 5000yearsenate candidate 3000yearhouse Changes in . DNA. that affect genetic information. Gene Mutations. Point Mutations – changes . in one or a few. nucleotides. Substitution. THE FAT CAT ATE THE RAT. THE FAT HAT ATE THE RAT. Insertion. What Are Mutations?. Mutation: . Changes . in the nucleotide sequence of . DNA. Mutagen: . A physical or chemical agent that changes DNA. Mutation May . occur . in:. somatic cells (body cells): . will not be . Erica, . Nao. , Christian and Justine. What are Homologous Structures? . Structures derived . from a common . ancestor or . same . evolutionary or . developmental . origin. May not perform . the same function but they share a common ancestral origin. . genomic . diversity. Sergei . Maslov. Department of Biosciences. Brookhaven . National . Laboratory, . New York. . Bacterial genome evolution . happens in cooperation with phages. +. =. Variation between E. coli strains. www.reco.on.ca Discipline Paths and OutcomesReal estate professionals (often called “agents”) in Ontario must follow the Real Estate and Business BrokersAct, 2002 (REBBA 2002) including a Co IN THE MATTER OF THEPROVISION OF BASIC GENERATION SERVICE FORTHE PERIOD BEGINNING JUNE 1 Docket No ER19040428ROCKLAND ELECTRIC COMPANYPROPOSAL FOR BASIC GENERATION SERVICEREQUIREMENTS TO BE PROCURED E Point mutations. single base change . silent mutation. no amino acid change. redundancy in code. missense. change amino acid. Changes the final protien. nonsense. change to stop codon. Stopping prematurely . The sequence of bases in DNA are like the letters of a coded message or even the letters of a simple alphabet. . If we change the sequence of the letters do we change the nature of the message?. That . Understand how they occur. Analyze the different types of mutations. Understand how mutations affect amino acid sequences and proteins. Objective. Central Dogma. DNA is transcribed into RNA, RNA is translated into proteins. Small-scale mutations. Missense mutations. Nonsense mutations. Silent mutations. Frameshift mutations. Large scale mutations. Causes. Mutagens. The results of mutation. Mutations. Genetic mutations are changes in the DNA sequence, caused by various mechanisms.. KEY CONCEPT:. . Mutations. are changes in genetic material.. VOCABULARY:. Mutation, point mutation, . frameshift. mutation, polyploidy. Mutations – extension from gene expression. . Changes in genotype. R. ecombination. 2. . Site-Specific . R. ecombination. 3. DNA . Transposition. Homologous Recombination at the Molecular Level. DNA BREAKS ARE COMMON AND INITIATE RECOMBINATION. Recombination repair DNA breaks by retrieving sequence information from undamaged DNA. mutation. Mutations. Actual Mutations . in fruit flies. What is a mutation?. A mutation is any change in a cell’s DNA. A mutation can occur in an individual gene. - results in a single changed protein.