PPT-Topic for the Class: Cell signaling through G-protein Coupled Receptor (GPCR)

Faculty Dr Hironmoy Sarkar Assistant Professor Department of Microbiology Raiganj University GPROTEIN COUPLED RECEPTOR GPCR Largest family of cell surface receptor Smell taste are perceived by GPCRs. Cell Signaling and Signal Transduction: Communication Between Cells. Signal transduction. Extracellular ligand: 1st messenger. Autocrine: ligand binds to producing cell. Paracrine: ligand binds to a neighbor cell. Pratt & . Cornely. , Chapter 10. Terms for Signal Transduction. Ligand. Receptor. Transducer. Effector. Second messenger. Target proteins/DNA. Ligands. Hormones vs Local mediators. Polar (insulin) vs nonpolar (steroidal hormone). o. pportunities . and. new hurdles . Ryan T. Strachan, PhD. Goals:. Convey my . enthusiasm about the . current and future states . of GPCR . Drug Discovery. Includes the first presentation of a novel screening strategy aimed at studying the unexplored pharmacology of GPCRs (screening the ‘. Believed to have evolved in prokaryotes and single-celled eukaryotes. Single-celled organisms. Bacteria use communication in quorum sensing. Short distance communication using local regulators. Secrete . Kuby Immunology. , . 7e: Chapter 3. Essential Concepts – 1. A cellular signal is any event that instructs a cell to change its metabolic or proliferative state. Signals are usually generated by the binding of a ligand to a complementary cell-bound receptor. Facilitator: Paula. Level. Introductory biology. Knowledge of students prior to unit. Cell theory. Characteristics of life. Homeostasis . Chemistry of macromolecules. Cell Signaling. Learning Goals:. Dr. Kevin Ahern. EGFR Signaling, Part 1. Epidermal Growth Factor Receptor (EGFR). EGFR Dimer. Autophosphorylated. Tyrosines in . Cytoplasmic Domain. Signaling Complex. Assembled on . Phosphotyrosines. NEIL MEHTA. BIOL 445.001. http://www.bcm.edu/pediatrics/cardiology/TGFBR2. http://en.wikipedia.org/wiki/TGF_beta_receptor_1. CELL SIGNALING PATHWAYS. HETERO-TETRAMERIC RECEPTOR COMPLEX FORMS UPON BINDING TO LIGAND (TGF. Participationin COREs(Coordinated Ocean-ice Coupled OceanCoupled Ocean--Ice Models Ice Models within the CSM Frameworkwithin the CSM Framework -HYCOM PanAm2.1 (hybri-Normally 2-26 vertical layers-CI AND . MOTILITY (BIOL 3373) . WHAT IS The CELL SIGNALING?. 2. How cells receive and respond to signals from their surroundings. On one hand, cell signaling regulates gene expression and controls the cell fate (proliferation, motility, differentiation and programmed cell death, or apoptosis).. Introduction. Cell signaling: . a biological mechanism that occurs in cells which gives cells an ability to receive or generate the signals in response to their surrounding environment.. Cell to cell communication . Pharmacodynamics. D-R Interact.ions and Pharmacodynamics. Pharmacodynamics. . Describes the actions of drugs on the body and the influence of drug . concentration on the magnitude of the response. The T-cell antigen receptor (TCR). The TCR is a complex of eight . transmembrane. proteins. The . خ± . and . خ² . chains form a disulfide-linked (. Sâ. €”S) dimer that is responsible for the recognition of antigenic peptides bound to class I and class II major . Alzayadneh. , PhD. Integrative Physiology and Pharmacology. 1. Introduction to Physiology (0501110) Spring 2013. Subject. Lecture No.. Lecturer. Pages in the 11. th. edition. textbook. Pages in the 12.