PPT-Topic for the Class: Cell signaling through G-protein Coupled Receptor (GPCR)

Faculty Dr Hironmoy Sarkar Assistant Professor Department of Microbiology Raiganj University GPROTEIN COUPLED RECEPTOR GPCR Largest family of cell surface receptor Smell taste are perceived by GPCRs. Cell Signaling and Signal Transduction: Communication Between Cells. Signal transduction. Extracellular ligand: 1st messenger. Autocrine: ligand binds to producing cell. Paracrine: ligand binds to a neighbor cell. VOCABULARY. directions: mark each term to indicate if you know it, are unsure, or don’t.. amplify . communication. deleterious elaborate. embryology evolution . fluid . mosaic model mechanism. . Signal Transduction Pathway. EXTRACELLULAR. FLUID. Plasma membrane. CYTOPLASM. Receptor. Signaling. molecule: ligand. Relay molecules in a signal transduction pathway. Activation. Believed to have evolved in prokaryotes and single-celled eukaryotes. Single-celled organisms. Bacteria use communication in quorum sensing. Short distance communication using local regulators. Secrete . Kuby Immunology. , . 7e: Chapter 3. Essential Concepts – 1. A cellular signal is any event that instructs a cell to change its metabolic or proliferative state. Signals are usually generated by the binding of a ligand to a complementary cell-bound receptor. Facilitator: Paula. Level. Introductory biology. Knowledge of students prior to unit. Cell theory. Characteristics of life. Homeostasis . Chemistry of macromolecules. Cell Signaling. Learning Goals:. Skochko. Chris Gilbertson. Reveals Important Features of one’s surroundings. Is it poisonous here? . Have things died here?. Is this food?. The absence of the sense of smell is called “Anosmia.”. AND . MOTILITY (BIOL 3373) . WHAT IS The CELL SIGNALING?. 2. How cells receive and respond to signals from their surroundings. On one hand, cell signaling regulates gene expression and controls the cell fate (proliferation, motility, differentiation and programmed cell death, or apoptosis).. Introduction. Cell signaling: . a biological mechanism that occurs in cells which gives cells an ability to receive or generate the signals in response to their surrounding environment.. Cell to cell communication . GPCR STRUCTURE AND FUNCTION G-protein-coupled receptors (GPCRs) or seven transmembrane domain receptors (7TM) comprise the largest superfamily of proteins in the body. In 6 Figure 1: Diversity Isshak. . Mrabet. . G-Protein. . coupled. receptors. B2 . adrenergic. receptor. Structural. . Biology. INDEX. Introduction. X-ray. Evolution. Structure . Inverse Agonist. Agonist. Comparisons. Active – inactive . Van Delden C, Iglewski BH. Cell-to-Cell Signaling and Pseudomonas aeruginosa Infections. Emerg Infect Dis. 1998;4(4):551-560. https://doi.org/10.3201/eid0404.980405. Main Theme. : . Interaction of proteins . is a key theme in cell signaling. 1. How Cells receive signals: . Electromagnetic (light). Mechanical (touch). Chemical **Most common!!**. 2. Cell Signaling Evolved EARLY in the History of Life. PowerPoint Image Slideshow. This work is licensed under a . Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. .. Communication. As with people, it is vital for individual cells to be able to interact with their environment. In order to properly respond to externals stimuli, cells have developed complex mechanisms of communication that can receive a message, transfer the information across the plasma membrane, and produce changes within the cell in response to the message. The ability of cells to communicate through chemical signals originated in single cells and was essential for the evolution of multicellular organisms. (credit: modification of work by Vincent and Bella Productions).