PPT-2. MEMBRANE AND RECEPTORS

Undergraduate Graduate Histology Lecture Series Larry Johnson Professor Veterinary Integrative Biosciences Texas AampM University College Station TX 77843 VIBS 443 and VIBS 602 . By Poppy and Jake. Intracellular receptors. Where are they?. What binds to them?. Intracellular (duh). Some are in the cytoplasm and some are in the nucleus.. Lipophillic. and hydrophobic ligands. E.g. Steroids (sex and . Learning Objectives. outline the roles of membranes within cells and at the surface of cells. state that plasma (cell surface) membranes are partially permeable barriers. describe, with the aid of diagrams, the fluid mosaic model of membrane structure. 1. . Chemoreceptors. : Sense specific chemicals. . eg. .(taste buds, lining of the nasal cavity = olfactory receptors, internal receptors like blood pH). 2. . Photoreceptors. : Sense visible light. . Signal transduction . General features of signal transduction. Type of cell signalling. Type of Signal . transducer/Receptors. signal transduction. T. he . signal. . represents the information, . that is detected by specific . Receptor. A receptor is a protein molecule usually embedded within the cell membrane with part of its structure exposed on the outside of the cell.. The protein surface is a complicated shape containing hollows, ravines, and ridges.. DR AMNA TAHR. ASSISTANT PROFESSOR. PHYSIOLOGY DEPARTMENT. KEMU. HORMONE. A  . hormone.   is a . chemical substance. produced in particular parts of organisms by specific cells, glands, and/or tissues and then transported to other parts of the body, with the intent of influencing a variety of physiological and behavioral activities, such as the . Receptor . Pharmacology . in . the . Peripheral . Nervous System (PNS. ):. a . Primer for . the. Cardiovascular. , Pulmonary, Renal. and . Musculoskeletal. (. MSK). . Modules. . E.M. . Silinsky. Ward 7-245 Tel: 503-8287. Prakriya’s. material. Selected Important Points. Competitive antagonists and D-R curves. bind . reversibly. to the same site as agonists. increasing concentration of agonist . overcomes. effect of the antagonist. is. afferent neuron.. (b) Receptor . regulates. afferent neuron.. To CNS. Afferent. neuron. Afferent. neuron. To CNS. Receptor. protein. Sensory. receptor. Stimulus. Neurotransmitter. Sensory. receptor. GPCR STRUCTURE AND FUNCTION G-protein-coupled receptors (GPCRs) or seven transmembrane domain receptors (7TM) comprise the largest superfamily of proteins in the body. In 6 Figure 1: Diversity Dr. Mohammed Hussein. M.B.Ch.B, MSC, . PhD, MRCPCH. , DCH (UK). Cellular Communication and Signaling. Types of Signaling. Autocrine. Direct . Signaling. Paracrine. Endocrine. Autocrine Signaling. Autocrine Signaling. Alzayadneh. , PhD. Integrative Physiology and Pharmacology. 1. Introduction to Physiology (0501110) Spring 2013. Subject. Lecture No.. Lecturer. Pages in the 11. th. edition. textbook. Pages in the 12. . by . Dr.Vani. Gupta. Homeostasis. Homeostasis. - maintaining internal stability within an organism and returning to a particular stable state after a fluctuation.. PowerPoint Image Slideshow. This work is licensed under a . Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. .. Communication. As with people, it is vital for individual cells to be able to interact with their environment. In order to properly respond to externals stimuli, cells have developed complex mechanisms of communication that can receive a message, transfer the information across the plasma membrane, and produce changes within the cell in response to the message. The ability of cells to communicate through chemical signals originated in single cells and was essential for the evolution of multicellular organisms. (credit: modification of work by Vincent and Bella Productions).