PPT-Tema 8 mRNA, tRNA y rRNA

CA García Sepúlveda MD PhD Last updated Jan 2019 Laboratorio de Genómica Viral y Humana Facultad de Medicina Universidad Autónoma de San Luis Potosí Tema 8 RNA Introducción mRNAs are single stranded RNA molecules. In all things of nature there is something of the. marvelous…. (Aristotle). RNA-Directed Polypeptide Synthesis. Genetic Code. ~ Universal & Redundant but not . ambiguous. 61 different . codons. 7.3.1. . State that transcription is carried out in a 5’→ 3’ direction.. Nucleotides are added in the form of ribonucleoside triphosphates. 7.3.2. . Distinguish between the . sense and antisense strands of DNA. Flow of genetic information in a cell. How do we move information from DNA to proteins?. transcription. translation. replication. protein. RNA. DNA. trait. DNA gets . all the glory,. but proteins do . 3.5.1: Compare the structure of RNA and DNA.. 3.5.1: Compare the structure of RNA and DNA.. IB Question: . Compare the structure and composition of DNA with RNA. . [4]. both are polymers of nucleotides / both nucleic acids;. (RNA). AcaDeca. 2013-2014. Characteristics of RNA. RNA is similar to DNA except for the fact that:. RNA’s . sugar is . r. ibose. O. ne . of the nitrogenous base is . u. racil. It is typically . s. base . uracil. . rather than thymine. An RNA molecule usually consists of a single strand rather than DNA’s double strand. Translation or protein synthesis : . is a process in which the genetic information present in m-RNA in the form of triplet codes (codons) directs the sequence of amino-acids in protein.  . From RNA to Protein. Translation. Steps of Translation. MESSENGER RNA. Polypeptide chains are specified by open reading frames. Three possible reading frames of E. coli . trp. leader sequence. An mRNA sequence is decoded in set of three nucleotides. is a small molecule, existing as a single-strand that is . folded. into a . clover-leaf shape. .. tRNA. The role of tRNA is to bring the amino acids to a ribosome where protein synthesis is taking place. (more on this later). 2. Fællesskab. Begrebskort. Tema 3 – Dag 1. 3. Fællesskab. Tema 3 – Dag 1. Begrebskort. 4. Fællesskab. Tema 3 – Dag 1. Begrebskort. 5. Fællesskab. Tema 3 – Dag 1. Begrebskort. 6. Kultur. Tema 3 – Dag . part 2. Prepared by Prof. Sabah Hassan -Coordination by Prof Sabah Linjawi BIO 702 L 5. Eukaryotic mRNAs. mRNA Production in Eukaryotes. 1. Eukaryotic mRNAs have 3 main parts. a. The 5’ leader sequence, or 5’ untranslated region (5’ UTR), varies in length.. Metabolic defects. studying metabolic diseases suggested that genes specified proteins. alkaptonuria. (black urine from . alkapton. ). PKU (phenylketonuria). each disease is caused by . non-functional enzyme. In a group of 4, you are also the Recorder. Determine the codon, anticodon, and . amino acid for the first codon in the P site. Tell . the . tRNA. maker and the Recorder.. For each subsequent codon, pass the codon wheel in this order: Recorder, . A primary transcript . is the initial, linear, RNA copy of a transcription unit—the segment of DNA between specific initiation and termination sequences. . The primary transcripts of both prokaryotic and eukaryotic . An Extension of the . tRNA. Paper . M. odeling . A. ctivity. Contents. Background (. pg. 3). Introduction and Resources. Instructions (. p. g. 4-5). Assembling the . tRNA. paper model. Exploring .