PPT-Epigenomic and regulatory genomics

of complex human disease Manolis Kellis MIT Computer Science amp Artificial Intelligence Laboratory Broad Institute of MIT and Harvard Recombination breakpoints Family Inheritance Me vs my brother. selection, . regulation, epigenomics, . disease. Manolis Kellis. MIT Computer Science & Artificial Intelligence Laboratory. Broad Institute of MIT and Harvard. Recombination breakpoints. Family Inheritance. selection, . regulation, epigenomics, . disease. Manolis Kellis. MIT Computer Science & Artificial Intelligence Laboratory. Broad Institute of MIT and Harvard. Goal: A systems-level understanding of genomes and gene regulation:. Overview and Capabilities: . . High Throughput Sequencing Facility (HTSG). Functional Genomics M. ammalian Genotyping Core (MGC). Corbin Jones. Faculty Director. Piotr . Meiczkowski . Technologies . What is Structural Genomics ?. Is the process of high-. throughtput. determination of 3-D structures of Biological macromolecules. What is the Goal of Structural Genomics ?. Provision of enough structural templates to facilitate homology modeling of most proteins.. “. User facility. providing high-throughput DNA sequencing & analysis in support of DOE missions in alternative . energy. , . carbon cycling . & . bioremediation. .”. Opened in 1999. ~240 UC Employees. 1. Part 1: . ChIP. -seq peak calling. Part 2. Analyzing . ChIP. -seq peaks. Saurabh Sinha. PowerPoint by Saba . Ghaffari. Edited by Brianna . Bucknor. & Giovanni Madrigal. Part 1: . ChIP. –Seq Peak Calling. Regulatory. . Genomics. | Saurabh . Sinha. | 2020. 1. PowerPoint by Saba . Ghaffari. Edited by Shayan Tabe Bordbar. In this lab, we will do the following:. .. Use command line tools to manipulate a ChIP track for BIN TF in D. Mel.. Heads of Medicines Agencies www.hma.eu An agency of the European Union European Medicines Agency www.ema.europa.eu GenomicsGenetics, Transcriptomicsand EpigeneticsubgroupreportDidier Meulendijks, Genomics and Society Nature (2014) “ …disorders not readily explained by standard tests can sometimes be diagnosed through genome sequencing and analysis.” The Origin of “Genomics& . Carl Pray. 1. Can advances in biology transform Asian agriculture? Challenges are large. Food production . Productivity growth . Crises – . Biological -Africa Swine Fever, corn stalk borer, fall armyworm, wheat rust. 1. Part 1: . ChIP. -seq peak calling. Part 2. Analyzing . ChIP. -seq peaks. Saurabh Sinha. PowerPoint by Saba Ghaffari. Edited by Giovanni Madrigal and Roberto . Cucalón. Tamayo. Part 1: . ChIP. –Seq Peak Calling. What . is . Functional. . Genomics?. RNA . Transcription/Gene. . Expression. Measuring Gene. . Expression. Microarrays. High-throughput. . Sequencing. Transcriptional. . Regulation. Transcription. Ian Green. Clinical Engagement and Education Business Manager. Strategy. Work undertaken by Genome One (part of the . Garvan. Institute). Work underway. Completion date . –. 17. th. , March 2017. Ravi Madduri. madduri@anl.gov. Joint work with Paul . Davé. , Lukasz . Lacinski. , Alex Rodriguez, . Dinanath. . Sulakhe. , Ryan Chard and Ian Foster. Globus Genomics is developed, operated, and supported by researchers, developers, and .