PPT-What’s Positive about Triple Negative Breast Cancer

Whats Positive about Triple Negative Breast Cancer Julie R Gralow MD Jill Professor Endowed Professor of Breast Cancer Director Breast Medical Oncology Seattle Cancer Care Alliance University of Washington School of Medicine. Dr. Courtney A. Vito, MD, FACS. Assistant Clinical Professor of . Surgcal. Oncology. City of Hope National Medical Center . 12/8/2014. Disclosures. No relevant financial disclosures. Serve as PI for the . For Fellows November 2016. American Cancer Society, 2015 Statistics. Risk Factors. Female. Age: median 57-62. Family history. Previous biopsies. Atypical changes. BRCA positive. Hormone replacement. Alcohol use. BRCA1 and BRCA2. Jennifer . Hardee. Normal function of the genes. BRCA1 & BRCA2 are in the same DNA repair pathway. Despite names, do not share any protein structure. Both are . tumor suppressors . Mohammad . Jahanzeb. , MD, FACP. Professor of Clinical Medicine, Hematology-Oncology. Director, UM Sylvester Deerfield Campus. Associate Center Director for Community Outreach. Sylvester Comprehensive Cancer Center. BRCA2 is a tumor suppressor gene responsible for DNA repair . BRCA2 was discovered in breast cancer tumors of patients without BRCA1 mutations. Mice knockouts discovered that BRCA2 is directly involved in double strand break repair. Alexis Clark. 1. . and Rebecca Haberman. 1. 1. Dept. of Biology, Mary Baldwin University, Staunton, VA. Introduction. . In the United States alone 1 in 8 women will develop invasive breast cancer over the course of their lifetime(1).. Interview with . Lauren . Segal. 15. th. March 2018. Top 5 cancers -South Africa. Breast , cervix ,Unknown Primary , Colorectal cancer and Uterus.. Breast cancer 22%. . Life time risk 1:28; white women 1:11 and black 1:51.. Professor of Medicine and Oncology. Karmanos Cancer Institute. Wayne State University. Breast Cancer 101. Biopsy +. Lumpectomy + RT. Mastectomy. SLNBx. ALND (> 3+ micro or macro preop and bx +). Standard, . A. University of Tennessee Medical Center – Knoxville. Departments of Pathology, Surgery, and Medicine. BREAST CANCER IN YOUNG AGE (≤40 YEARS): THE UNIVERSITY OF. . TENNESSEE MEDICAL CENTER AT KNOXVILLE 10 YEAR EXPERIENCE. group. of diseases. . All forms of cancer cause cells in the body to change and grow out of control. . Most types of cancer cells form a lump or mass called a . tumor. . . The tumor can invade and destroy healthy tissue. Cells from the tumor can break away and travel to other parts of the body. There they can continue to grow. . Most of these lesions are benign. Breast cancer is 2. nd. most common cause of cancer deaths in women, following. carcinoma of the lung. . The clinical significance of the . benign. conditions:. 1- possible clinical confusion with malignancy. L. MEYSKENS, D. (32, 33), and hormonal (42, 46, (60, 78). 57, 66, cancer in is less Klinefelter'n syndrome with male authors measured et al. the formation ofestrone results rerrmin in males been repo Percent with Patients. Number of Patients (Median). ER-positive, HER2-negative breast cancer for whom you ordered a genomic assay. 92. 14. Metastatic ER-positive, HER2-negative . breast cancer. 96. 10. breast. . cancer. . needs. . different. . therapeutic. . strategies. . than. HER-2 . enriched. . tumors. ?. Patrizia Vici. Cleopatra. TDM-1: . EMILIA. Verma. S ESMO 2012. (. Activity. . HR+.