PPT-Tumor -genesis Tumor mutations

Antigen presentation Immune recognition Immune silencing Stage Model for immuno oncology Genomics to diagnose stages Tumor genesis Tumor mutations Antigen presentation Immune recognition. DNA pol error rate . ~. 10. -9. per base . copied. How many errors in a . “typical” . somatic cell?. Most errors don’t have detectable effects. But some errors do: . . oncogenes. N. . – dominant. Colin Reisterer and Nick Swenson. S. . Maheswaran. et al. . The New England Journal of Medicine. . 2007. http://www.all-cancer-treatments.com/types-of-lung-cancer.html. Clinical background: Non-small cell lung cancer (NSCLC). Ben Ho Park MD PhD. Johns Hopkins University. Financial Disclosures. I have financial relationships with commercial entities that are relevant to the content of this presentation.. Royalties from Horizon Discovery, LTD. The . name Genesis = Beginning. Comes from the Greek.. Can also mean origin, birth, and generation. Hebrew from first word "in the beginning.". Written by Moses. Date . written: 1490 BC to 1420 BC.. The . name Genesis = Beginning. Comes from the Greek.. Can also mean origin, birth, and generation. Hebrew from first word "in the beginning.". Written by Moses. Date . written: 1490 BC to 1420 BC.. npg REVIEW Implications of mitochondrial DNA mutations and mito npg Dr. . Heyam. . Awad. MD, . FRCPath. ILOS. 1.list the main environmental causative agents of cancer.. 2. understand the difference between direct and indirect acting chemical carcinogens.. 3. understand the pathogenesis of cancer development due to several etiologic agents.. Given a mutation, identify its type. Predict how a mutation will affect a protein.. Mutations. Changes in genetic material (DNA). 2 main types of mutations. Point mutation- change in one or a few nucleotides (letters). The sequence of bases in DNA are like the letters of a coded message or even the letters of a simple alphabet. . If we change the sequence of the letters do we change the nature of the message?. That . Conditional mutations. Point mutations. In . point mutations . the sequence of the DNA has been altered at a single position. Where this change consists of replacing one nucleotide by another, it is known as a . Cécile Jovelet. Postdocoral. . fellow. Translational. . research. . lab. Gustave Roussy Institute, France. Introduction . 12/04/2017. 2. Lung cancer: . third most frequent cancer. Non-Small Cell Lung Cancer (NSCLC): 80% cases of lung cancer. after human tumor initiation? (and why this might be important!) Darryl Shibata Department of Pathology University of Southern California Keck School of Medicine Los Angeles, CA dshibata@usc.edu ~10 There are two basic types of mutations:. Gene mutations - mutations that produce changes in a single gene. Chromosomal mutations - mutations that produce changes in whole chromosomes. Gene mutations . glioblastoma. genes and core pathways. By: Katie . Adolphsen. , Robin Aldrich, Brandon . Hu. , . Nate . Havko. The Cancer Genome Atlas: TCGA. Collaborative effort . $100 million pilot project. Funded by National Cancer Institute and the National Human Genome Research Institute of the National Institutes of Health.