PPT-Cancer and the Immune System

Dr Refif S Al Shawk 2023 After reading this lecture you should be able to Demonstrate how specific innate and adaptive immune response pathways and molecules are involved in the recognition and eradication of cancer cells. .. . Preliminary results. . Dimitra . Kerdidani. , . Vaso. . Karavana. , Sofia . Magkouta. , Aggeliki . Meligova. , Charis Roussos, Spyros . Zakynthinos. , Ioannis . Kalomenidis. , Maria Tsoumakidou. . Chapter 40. Agents of Disease. The human body provides a suitable environment for many microorganisms: it is moist, warm and full of nutrients.. Not all microorganisms are harmful; some are beneficial. Additional key terms. Lymph. Having to do with lymph or lymphatic system. Intercellular fluid as it returns to the venous circulatory system. Removes waste products from the cells. Must be filtered by the lymph nodes before it reenters the circulatory system . Cancer Immunoediting . Elimination➛ Equilibrium➛ Escape. Proinflammatory Reaction . Within the Tumor Microenvironment. Tumor Cell-Mediated Immune Escape. Aberrant Signal 1, 2, or 3 in the Tumor Microenvironment. Michael Dougan, MD, PhD. Director of the Immunotherapy Mucosal Toxicities Program. Massachusetts General Hospital. 21 March 2018. Cancer is like an infection that can’t be cleared. Mutations can be recognized. Innate Immunity. Receptors on T and B Cells Are Specific for Each Antigen. Innate and Adaptive Immune Systems. Antigen Presentation. Adaptive Immunity. Function of the Immune System. Tumor Escape Mechanisms. Immunotherapy. George Weiner, MD. Director, Holden Comprehensive Cancer Center. Professor, Department of Internal Medicine. George Weiner, MD. Disclosure. Consultant and Research Funding. Checkmate Pharmaceuticals. Emerging Concepts on PD-L1: Immune Check Point Blockade in Cancer Short Presentations on Emerging Concepts (SPEC) Version 1.0, rev. 9/7/2016 © 2018 College of American Pathologists (CAP). All rights reserved. By Renira Rugnath and Jeshanah Johnson . Basics . Homeostasis, or a "steady state," is a continual balancing act of the body systems to provide an internal environment that is comparable with life. The two liquid tissues of the body, the blood and lymph have separate but interrelated functions in maintaining this balance. They combine with a third system, the immune, to protect the body against pathogens that could threaten the organism's viability. . Your defense against the antigens of the world. The webinar recording of this presentation will be available at:. www.nspwebinars.com. Phone: 1-712-432-0453 PIN 8626. (Not a toll-free . call. ). Be in our Cancun Giveaway Drawing!. ecognize. A. ttack. D. estroy . A. nd . R. emember. Bodies defense against pathogens. Immune System recognizes the identity of foreign substances. Antigens are found on the cells of all organisms and your body is able to identify your own cells and tell when a foreign cell has entered the system. The Immune System. The immune system is a group of cells & soluble molecules, which interact & distinguish patterns in the body as “self” or “non-self,” in order to eliminate those that are “non-self.”. The initiative primarily set out to guide clinicians, mainly . rheumatologists, but also in some countries internists and immunologists, who have to play a pivotal role in developing with the oncologists a patient-centred approach to improve the diagnosis and the management of rheumatic immune-related adverse events (irAEs).. What is the Immune System?. The immune system is a vast network of cells and tissues.. Located throughout your body.. Involves numerous types of cells, organs, proteins, and tissues.. The immune system can distinguish between your tissues and foreign tissue/ invaders..