PPT-Repair of DNA Damage and Replication Errors

One of the benefits of the double stranded DNA structure is that it lends itself to repair when structural damage or replication errors occur Several kinds of chemical change may cause damage to DNA. MUTAGENESIS. DNA DAMAGE. DNA REPAIR. RECOMBINATION. MUTAGENESIS. Mutations. Mutations are heritable permanent changes in the base sequence of DNA.. Point mutations may be . transitions. (e.g. GC→AT) or . cellular sensing/responding, . and repair. Rebecca Fry, Ph.D.. DNA damage. DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. . DNA damage and repair and their role in carcinogenesis. A DNA sequence can be changed by copying errors introduced by DNA polymerase during replication and by environmental agents such as chemical mutagens or radiation. Semiconservative vs. Conservative. DNA Polymerase. RNA Primase. Okazaki Fragments. Replication Errors. TeachWithFergy . Preview File. . Please . enjoy this preview of your Power Point. . Some slides appear blank because they have been removed.. Dr. Kevin Ahern. Structure. Structure. Structure. One Strand of DNA. Structure. Introduction. Structure. Introduction. DNA Structure. DNA Forms. Semi-Conservative Replication. Discontinuous. Replication. and repair. Rebecca Fry, Ph.D.. DNA damage. DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. . Principles of Molecular Biology. Group Members. Maira Aleem. Bilal Naveed. Tanzeela Raza. Maheen. Malik. Zaigham. Abbas. DNA Structure. DNA = Deoxyribose nucleic . acid.. Four Nucleotides . - A. denine.  . Author: Michael Fenech. Affiliation: Genome Health Foundation, North Brighton, SA, 5048, Australia. Email: . mf.ghf@outlook.com. . Introduction. Life as we know it depends entirely on the capacity of cells to utilize energy and molecules in the environment for cellular function and reproduction. . If we have an error one in a million this mean we will have 3000 errors during each replication cycle of the genome.. The genome of a typical mammalian cell . accumulates many . thousands of lesions during a 24-hour period.. . REPLICATION – GENERAL PRINCIPLES. START. Must be ready . Must know where to start . FINISH. Must all finish . Must ensure that each piece of DNA is replicated only once . Therefore must know where to finish . of intense freckling and high melanoma incidence, related to UV sensitivity. The syndrome actually results from defects in any of nine genes involved in repair of UV damage. C. EPAIRING DAMAGED OR CORE View metadata, citation and similar papers at core.ac.uk provided by University of Birmingham Research Portal Targeting DNA repair for anti-cancer therapy Thomas Helleday1,2,*, Cecilia Lundin, Be ABSTRACT Chemotherapy often targets dividing cells by causing DNA damage that leads to replication-dependent toxic lesions. Cells possess several overlapping DNA damage repair pathways that allow them REPLICATION ERRRORS AND THEIR REPAIR. The nature of mutations. Transitions. Transversions. Some replication errors escape proofreading. Mismatch repair removes errors that escape proofreading. Structure of .