PPT-Repair of DNA Damage and Replication Errors

One of the benefits of the double stranded DNA structure is that it lends itself to repair when structural damage or replication errors occur Several kinds of chemical change may cause damage to DNA. MUTAGENESIS. DNA DAMAGE. DNA REPAIR. RECOMBINATION. MUTAGENESIS. Mutations. Mutations are heritable permanent changes in the base sequence of DNA.. Point mutations may be . transitions. (e.g. GC→AT) or . cellular sensing/responding, . and repair. Rebecca Fry, Ph.D.. DNA damage. DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. . Nucleotide Excision Repair XP and CS. BiS222. By . Jooyoung. Chang . 장주영. Class #01 / Stu. #20091259. Assembling a Car. An analogy. Steps in building a CAR. Steps in building a . PROTEIN. Q: Most . (. Danio. . rerio. ) . as a model. Chris A. . McCabe. 1. , Chris W. Theodorakis. 2. , Theodore B. Henry. 1. and Mark G. J. . Hartl. 1. Introduction . Environmental stressors can damage the DNA of aquatic organisms. and repair. Rebecca Fry, Ph.D.. DNA damage. DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. . Directions: Front of card write term. On back write definition and draw picture . Chromosomes. Thread-like structure made of coiled DNA. Gene. Segment of DNA that codes for a specific trait. Nucleotide. (Chapter 12). Presented by Dr. Laurie M. Erickson. Chair of the Department of Health Sciences. Blitstein Institute of Hebrew Theological College. Chicago, IL, USA.. 12.1-12.2 Mutations . Mutation:. any heritable change in the genetic material. In . their 1953 announcement of a double helix structure for DNA, Watson and Crick stated, . "It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.". If we have an error one in a million this mean we will have 3000 errors during each replication cycle of the genome.. The genome of a typical mammalian cell . accumulates many . thousands of lesions during a 24-hour period.. . REPLICATION – GENERAL PRINCIPLES. START. Must be ready . Must know where to start . FINISH. Must all finish . Must ensure that each piece of DNA is replicated only once . Therefore must know where to finish . ABSTRACT Chemotherapy often targets dividing cells by causing DNA damage that leads to replication-dependent toxic lesions. Cells possess several overlapping DNA damage repair pathways that allow them REPLICATION ERRRORS AND THEIR REPAIR. The nature of mutations. Transitions. Transversions. Some replication errors escape proofreading. Mismatch repair removes errors that escape proofreading. Structure of . . What is DNA?. DNA is a . Nucleic Acid in the nucleus. Polymer of . Nucleotides. Each nucleotide consists of. Deoxy. ribose (5-carbon sugar) . Phosphate group. a nitrogen-containing base. Four bases. preserve genetic information.. transfer genetic information to new cells as the strands of DNA are copied.. DNA Replication. In . DNA replication. ,. the strands in the original or parent DNA molecule separate to allow the synthesis of complementary DNA strands..