PPT-Transfusion in Sickle cell anemia

Dr Soheila zareifar Department of pediatric hematologyoncology Shiraz university of medical sciences Qeshm 2018 Transfusion in Sickle Cell In sickle cell disease transfusions improve blood flow by reducing the proportion of red cells capable of forming sickle hemoglobin polymer . By: Jarrett . Devose. , Jordan Patten, and Michael Lamb. Sickle cell anemia is a disease passed down through your family, it causes red blood cells to form in a odd crescent shape. Red blood cells are usually shaped like a . b. d. g. a. a. Chromosome 16. Chromosome 11. 25%. 25%. a. a. b. d. g. 25%. 25%. 48%. 48%. 1.5%. 0.5%. 1.5%. 0.5%. Hemoglobin synthesis. a. a. a. a. a. a. b. g. d. b. d. g. HbA. HbF. HbA. 2. 98%. ~1%. Jenny Pham. Protein Structure & Function. Spring 2015. Outline. Normal Adult Hemoglobin (. Hb. A). Function: Deoxygenated v. Oxygenated. Mutation in . Hb. A. Sickle Cell Hemoglobin (. Hb. S). Sickle Cell Anemia. Katie Coltharp and Mariela Saenz. Names of Disorder. HbS. disease. Hemoglobin S disease. Hemoglobin SS disease. Sickling. disorder due to hemoglobin S. Sickle cell disease (broad term). Sickle cell disorders (broad group of conditions). CO binds to your . hemoglobin. , prevents oxygen from binding.  Can be fatal.   It is a "silent killer" as people often die in their sleep when a heater fails.. Carbon monoxide deaths are more likely to occur in winter. What is the most common genetic disorder in the United States?. Background . Inheritance. Pathophysiology. Diagnostic . testing. Prognosis. Management of acute illness. Long-term management. Treatment options. April 24, 2017. What is SSD?. SSD is an autosomal recessive disorder of a point mutation in the beta globulin chain in hemoglobin.. SSD is an autosomal recessive disorder of a point mutation in the beta globulin chain in hemoglobin.. Ali Al Khader, M.D.. Faculty of Medicine. Al-Balqa’ Applied University. Email: ali.alkhader@bau.edu.jo. Sickle Cell Anemia. The . most common familial hemolytic . anemia in . the . world. Sickle . cell . (SCAFO). By Pastor Marcia Taylor, Founder, CEO. 2021. Our programs are specifically designed and dedicated to accommodating the needs of those who are faced with the challenges of Sickle Cell such as access to care, socio-economical support services, mental health, substance abuse, family and/or care provider educational support, and isolation. . Dr. M. . Sofi. MD; FRCP (London); . FRCPEdin. ; . FRCSEdin. The term . sickle cell disease . (SCD) is generally used to describe all of the conditions associated with the phenomenon of . sickling. , whereas the term . Objectives. Describe the physiology of oxygen delivery. List risks and benefits of red blood cell transfusions. Discuss the evidence regarding thresholds for red blood cell transfusion. Explain methods to prevent the need for intra- and post-operative transfusions. Division of Blood Diseases and Re s o u rc e s EALTHational Heart, Lung, and Blood InstituteDivision of Blood Diseases and ResourcesUBLICATIONRIGINALLYREVIOUSLYOURTH II Preface. . . . . . . . . . . . Disease Education 5/17 Care of patients with sickle cell disease for primary care providers and emergency room personnel Table of Contents Chapter 1: Background About Sickle Cell Disease and Making t F.I.B.M.S (Int. Medicine), F.I.B.M.S (Hematology). What is SCD ?. Sickle cell . diseases . (SCD) . are . inherited chronic . hemolytic anemia resulting . from the presence of a mutated form of hemoglobin, .