PPT-Transfusion in Sickle cell anemia

Dr Soheila zareifar Department of pediatric hematologyoncology Shiraz university of medical sciences Qeshm 2018 Transfusion in Sickle Cell In sickle cell disease transfusions improve blood flow by reducing the proportion of red cells capable of forming sickle hemoglobin polymer . EXAMINING PREVALENCE OF TOBACCO,. ALCOHOL, ILLICIT DRUG USE IN. ADULTS WITH SICKLE CELL ANEMIA. Catherine A. Seamon, Darlene T. Allen, . James G. Taylor VI, Jonathan Wilson, Gregory J. Kato . Disclosures. &. Intercollegiate Athletics. Sickle Cell Trait. (Hereditary Condition) . Red blood cells (RBC’s) are normally round, circular or disc shaped.. RBC’s have hemoglobin component (helps carry oxygen) and platelets (helps in clotting). b. d. g. a. a. Chromosome 16. Chromosome 11. 25%. 25%. a. a. b. d. g. 25%. 25%. 48%. 48%. 1.5%. 0.5%. 1.5%. 0.5%. Hemoglobin synthesis. a. a. a. a. a. a. b. g. d. b. d. g. HbA. HbF. HbA. 2. 98%. ~1%. Jenny Pham. Protein Structure & Function. Spring 2015. Outline. Normal Adult Hemoglobin (. Hb. A). Function: Deoxygenated v. Oxygenated. Mutation in . Hb. A. Sickle Cell Hemoglobin (. Hb. S). Sickle Cell Anemia. was developed to create a greater awareness in . the Nashville . community of Sickle Cell Disease and to raise . funds for . patient care, . social services. , and research. . All . proceeds from the event . Presenter: Bridget H. Wilson, Ph.D., MS, RN. Introduction. Sickle cell disease (SCD) pain continues to emerge among adolescents. Over 98,000 individuals are believed to have SCD within the United States. . Katie Coltharp and Mariela Saenz. Names of Disorder. HbS. disease. Hemoglobin S disease. Hemoglobin SS disease. Sickling. disorder due to hemoglobin S. Sickle cell disease (broad term). Sickle cell disorders (broad group of conditions). Gary Strokosch, MD. Jane Litvin, MS. Introduction. History of . sickle cell disease . (SCD). Present in Africa for at least . 5,000. . years. 1910-. . Discovered in US. Walter Clement Noel – dental student from Grenada studying in Chicago. . Dr. M. . Sofi. MD; FRCP (London); . FRCPEdin. ; . FRCSEdin. The term . sickle cell disease . (SCD) is generally used to describe all of the conditions associated with the phenomenon of . sickling. , whereas the term . a sign . of an underlying . disorder. There are several kinds of anemia. . A. . physiologic . approach classifies anemia according to whether. the deficiency in erythrocytes is caused by a defect in . globin. chains. Abnormalities in these proteins are referred to as . hemoglobinopathies. Two hemoglobin gene clusters are involved in the production of hemoglobin and are located at the end of the short arm of chromosomes 16 and 11, respectively. . Ass. Prof. . Abeer. . Anwer. Ahmed. Sickle cell . anaemia. Ass. Prof. . Abeer. . Anwer. Ahmed. Sickle cell disease is a group of . haemoglobin. disorders . resulting from . the inheritance of the sickle β‐. Division of Blood Diseases and Re s o u rc e s EALTHational Heart, Lung, and Blood InstituteDivision of Blood Diseases and ResourcesUBLICATIONRIGINALLYREVIOUSLYOURTH II Preface. . . . . . . . . . . . F.I.B.M.S (Int. Medicine), F.I.B.M.S (Hematology). What is SCD ?. Sickle cell . diseases . (SCD) . are . inherited chronic . hemolytic anemia resulting . from the presence of a mutated form of hemoglobin, .