PPT-Amino Acid Degradation and Nitrogen Metabolism

Chapter 30 Stryer Short Course Overview Amino Acid Catabolism Nitrogen removal Urea Cycle Metabolism of carbon backbone Amino acid catabolism Amino acids from diet or protein turnover Salvaged for use in proteins or catabolized. . Cytochrome C in Humans Compared to Other Species Using Bioinformatics. We live in a human-centric world.. Human Metabolism. Sugar +. O. xygen. Energy!. Aerobic respiration. 1. Glycolysis. 2. Citric acid cycle. 15 . Slides. AMINO ACID . CATABOLISM. fig 18-1. fate of amino nitrogen in mammals. fig 18-2. metabolism of amino nitrogen in liver. fig 18-2. nitrogen removal molecules…. fig 18-2. metabolism of amino nitrogen in liver. Pratt and . Cornely. Chapter 18. Overview. Nitrogen assimilation. Amino acid biosynthesis. Nonessential aa. Essential aa. Nucleotide biosynthesis . Amino Acid Catabolism. Urea Cycle. Juicy Steak Part 2. Pratt and . Cornely. Chapter 18. Overview. Nitrogen assimilation. Amino acid biosynthesis. Nonessential aa. Essential aa. Nucleotide biosynthesis . Amino Acid . Catabolism. Urea Cycle. Juicy Steak Part 2. Amino . Acids. In a transamination reaction, . aspartate transaminase (AST) . catalyzes the reversible transfer of an amino group between glutamate and aspartate.. an . α. -amino group is transferred from an amino acid to an . Nitrogen Metabolism. Nitrogen Forms in the Body. Nitrogen Balance Critical. Body Must Make and Break Down Amino Acids. Nitrogen Also Needed for Synthesis of. Nucleotides (ATP, GTP, CTP, UTP, dATP, dCTP, dGTP, dTTP). CATABOLISM. fig 18-1. fate of amino nitrogen in mammals. fig 18-2. metabolism of amino nitrogen in liver. fig 18-2. nitrogen removal molecules…. fig 18-2. metabolism of amino nitrogen in liver. pg 677. building blocks for protein synthesis. precursors of nucleotides and heme. source of energy. neurotransmitters. precursors of neurotransmitters and hormones. Outline of amino acid degradation. The liver is the major site of degradation for most amino acids, but muscle and kidney dominate the degradation of specific ones. . 1. Nitrogen Fixation. 2. Amino Acid Biosynthesis. Nitrogen. is an essential element found in . proteins. , . nucleic acids . and many other molecules. Biologically available nitrogen is scarce. Approximately 75% are reutilized.. The excess nitrogen forms urea.. Proteins represent 10-15 % of total energy supply.. Digestion and Absorption of Proteins.. The . α. -amino group of many amino acids is transferred to . Learning Objectives :. 1. Know the groups of . a.a. . biosynthetic families. 2. The enzymes and coenzymes involved in the synthetic pathways. 3. The enzyme deficiencies of each pathway.. 4. The consequences of the inborn errors of metabolism. VBC-607. Unit-1. P.G.. 6.11.2020. MAPLE SYRUP URINE DISEASE. Also known as Branched chain ketonuria. Partial or complete deficiency of branched-chain . α . keto acid dehydrogenase (a multienzyme complex associated with inner membrane of mitochondrion). 2. Aged proteins, damaged or modified proteins and non-functional proteins of the body undergo degradation. . 3. Protein degradation may play important role in shaping tissues and organs during pregnancy and development.. KWWSVGRLRUJ316 3XEOLVKHGRQOLQHE\&DPEULGJH8QLYHUVLW\3UHVV in the studies are undertaken, mat