PPT-The Cancer genome atlas (TCGA) and the search for a CUP genetic/epigenetic signature

The Cancer genome atlas TCGA and the search for a CUP geneticepigenetic signature Manel Esteller MD PhD Director Josep Carreras Leukaemia Research Institute IJC Director Cancer Epigenetics and Biology Program PEBC. Overview. Focus on:. Structure of DNA/RNA – can I draw it or interpret drawings. DNA Replication – can I describe the basic process. RNA Transcription – can I explain role of each type of RNA. Biosynthesis of Proteins – can I explain the basic process. 02-223 Personalized Medicine:. Understanding Your Own Genome. Fall 2014. Overview. Course website: . http://www.cs.cmu.edu/~sssykim/teaching/f14/f14.html. All lab reports and term paper should be submitted to blackboard by midnight on the due . Genome sequencing. Next Gen sequencing. Genomics = resources. genome maps. genome sequences. genome clones. DNA microarrays. whole gene collections. functional genomics!. 1980- 1998. 1977- 2003. DNA mapping. Lucio Miele, M.D., Ph.D.. Part III: “The Pianist and the Piano”. Bad music, . stem cells and . bad luck. The genetic piano. The genetic piano - 2. Our genomes can be compared to piano keyboards, where each key is a gene. for Colorectal . Cancer. Ulrike (. Riki. ) Peters. Fred Hutchinson Cancer Research Center. University of Washington. Overview. Significance and rationale. . Current efforts on rare and less frequent variants. Tim Graubert, MD. Division of Oncology, Stem Cell Biology Section. Washington University School of Medicine. Siteman Cancer Center. Genome Center at Washington University. Genome Center Leadership. Rick Wilson. Global High-Incidence Regions Identifies Crucial Genes and Potential Cancer Markers. Contributors: . Fazlur Rahman Talukdar. , Sheila C. Soares Lima, Rita . Khoueiry. , . Ruhina. Shirin . Laskar. , . 15 . Gene . E. xpression . S. ignature . to . Detect . a . Subgroup . D. riven . by MAPK . Signalling. Abstract No: 1777 . 1. Centre for Cancer Research and Cell Biology, Queens University Belfast, Northern Ireland, . cBioPortal. . Nitish . Mishra. TCGA history. TCGA is a project, begun in 2005, to catalogue genetic mutations responsible for cancer, using genome sequencing.. TCGA is supervised by the Center for Cancer Genomics and the National Human Genome Research Institute. A three-year pilot project, begun in 2006, focused on characterization of . 1859 Discovery: Natural Selection Charles Darwin wrote “On the Origin of Species by Means of Natural Selection, or the Preservation of Favored Races in the Struggle for Life.” 1865 Discov Whole genome sequencing of babies REASONS FOR USING WHOLE GENOME SEQUENCING IN BABIES There are a number of possible reasons for carrying out whole genome or exome sequencing Seeking a diagnosis for a Benjamin Neale, PhD. Boulder Workshop. Content warning: eugenicists. Sick individuals and sick populations Rose 1985. Mendelian. Genetics. Co-dominance. East 1915: Inheritance of Corolla Length in . Imaging . Information Correlated with TCGA Samples. Fred Prior. 1. , John Freymann. 2. , . Bruce Vendt. 1. ,. . Ken Clark. 1. , . Justin Kirby. 2. , Lawrence Tarbox. 1. , Paul Koppel. 1. , . Stephen Moore. cyto. )genetics in a diagnostic setting. Basic technical aspects such as conventional karyotyping, methods and principles in fluorescence . in situ . hybridization (FISH), micro-array genomic profiling, QPCR, gene sequencing and new technologies such as Optical Genome Mapping and Whole Genome sequencing will be presented. In addition to the various laboratory techniques, there will be presentations on quality assessment, ISCN nomenclature and genetic aberrations in different types of leukemia. The program includes two panel discussions (for live audience only) in which participants will have the opportunity to ask questions and present their own patient cases..