PPT-MCB- Signal Transduction Lecture 1

General Concepts of Signal Transduction Cell Communication Types of Receptors Molecular Signaling Receptor Binding Scatchard Analysis Competitive Binding Second Messengers Signaling throughout Evolution. In this lecture we want to revisit power for the continuous time domain with a view to expressing it in terms of the frequency spectrum First though we should review the derivation of average power using the complex Fourier series 51 Review of Discr DR AMINA TARIQ. BIOCHEMISTRY. Survival of a multicellular organism depends on their ability to adapt to the constantly changing environment.. Intercellular communication mechanisms are necessary for this adaptation.. Chapter 13, . Stryer. Short Course. Signal Transduction. Signal from exterior of cell must affect interior of cell. Through the membrane. Amplification of signal. Ability to turn off. A few pathways…. . Enzyme-linked . receptors. Nuclear receptors. Stochasticity. in . signalling. .. Enzyme-linked receptors. . signalling. through growth factors, hormones, cytokines. acting locally at very low concentrations (10. Organisms. can function normally only if:. All the cells of their different organs communicating effectively with their surroundings. . Once a cell picks up a hormonal or sensory signal, it must transmit this information from the surface to the interior parts of the cell—. . Signal Transduction Pathway. EXTRACELLULAR. FLUID. Plasma membrane. CYTOPLASM. Receptor. Signaling. molecule: ligand. Relay molecules in a signal transduction pathway. Activation. Signal transduction . General features of signal transduction. Type of cell signalling. Type of Signal . transducer/Receptors. signal transduction. T. he . signal. . represents the information, . that is detected by specific . Index. Introduction. Discovery. Linkage data from transduction. Specialized transduction. Lytic and Lysogenic Cycle. Introduction. Transduction is the process by which DNA. . is transferred from one bacterium to another by a virus.. Believed to have evolved in prokaryotes and single-celled eukaryotes. Single-celled organisms. Bacteria use communication in quorum sensing. Short distance communication using local regulators. Secrete . Dr. Kevin Ahern. EGFR Signaling, Part 1. Epidermal Growth Factor Receptor (EGFR). EGFR Dimer. Autophosphorylated. Tyrosines in . Cytoplasmic Domain. Signaling Complex. Assembled on . Phosphotyrosines. More than 4 years experience in developing and analyzing mathematical models of complex bio-chemical reaction networks 10 Journal papers, 1 book chapter, 6 peer-reviewed conference papers, and 7 Z. Huang, Y. Chu, B. Cunha, and J. Hahn, Cellular Signaling. Autocrine Signals . Diffuse from one part of a cell to another part of the same cell. Synaptic signaling. Neurotransmitter is the signaling molecule. Occurs in the animal nervous system. Outline. Review of Photosynthesis. Finish up Cam plants . Cell-Cell Communication. Local vs Long distance. Three Stages of Signaling. Reception. Transduction. Response. Photosynthesis - Overview. “Fixing” Carbon.