93009 Intracellular Signaling Cell Signaling Basics Intercellular Endocrine Paracrine Autocrine Juxtacrine Intracellular Hydrophobic Hydrophilic Gasses Fall Semester Lab Meeting 3 93009 ID: 490300
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Fall Semester, Lab Meeting 39/30/09
Intracellular SignalingSlide2
Cell Signaling BasicsIntercellular: EndocrineParacrineAutocrineJuxtacrineIntracellularHydrophobicHydrophilicGasses
Fall Semester, Lab Meeting 3
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Intracellular Signaling BasicsGenerated en mass in response to receptor activation .Diffuse away from source to other specific parts in cellPass signal on by binding to and altering behavior of selected signaling proteins or target proteins.
Fall Semester, Lab Meeting 3
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Intracellular SignalingMain types of signaling molecules:Relay proteinsMessenger proteinsAdaptor proteinsAmplifier proteinsTransducer proteinsBirurcation proteinsIntegrator proteinsLatent gene regulatory proteins
Fall Semester, Lab Meeting 3
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Intracellular Signaling SystemscAMPPhosphoinositolArachidonic acidcGMPTyosine kinase
Fall Semester, Lab Meeting 3
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MAPK/ERKHedgehogTGP betaJAK-STAT
Fall Semester, Lab Meeting 3
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Intracellular Signaling PathwaysSlide7
Intracellular Signaling: Molecular SwitchesOn receipt of a signal they switch from inactive to activeLargest class activates or deactivates proteins by phosphorylationGTP binding is the next largest classActive when GTP is bound and inactive when GDP is bound
Fall Semester, Lab Meeting 3
9/30/09Slide8
Intracellular Signaling: ProcessingMany complex signals come in with multiple interactionsScaffold proteins
Fall Semester, Lab Meeting 3
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Intracellular Signaling: Cell Response Response varies from linear gradient to abrupt changesIf receptors act independently, then a linear gradient normally occursIf quick change occurs normally more than one effector molecule is required. Activation of one enzyme and inhibition of the reverse reaction also causes quick change
Fall Semester, Lab Meeting 3
9/30/09