Pharmacokinetics and Pharmacodynamics of

Pharmacokinetics and Pharmacodynamics of
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Pharmacokinetics and Pharmacodynamics of Intravenously Administered Tranexamic Acid in Horses Anne Werum Julie Dechant, DVM, DACVS, DACVECC Introduction Tranexamic acid (TEA) antifibrinolytic drug Prevent clot breakdown and prolong clot

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Pharmacokinetics and Pharmacodynamics of Intravenously Administered Tranexamic Acid in Horses Anne Werum
Julie Dechant, DVM, DACVS, DACVECC<br>
02
Introduction Tranexamic acid (TEA) = antifibrinolytic drug
Prevent clot breakdown and prolong clot maintenance
Antifibrinolytic drug indications
Abdominal and intra-articular bleeding
Intra-op and post-op
Colic surgery
Sinus surgery
Castration
Traumatic injury<br>
03
Introduction: Lysine Analog MoA Lysine analog binds to lysine binding site on plasminogen
Plasminogen cannot bind to fibrin
Plasminogen cannot break down fibrin clot<br>