PPT-microRNA , Cancer Epigenetics and

Bioinformatics SPRING 2019 BIO307 Jasmin Šutković 2 9th May 2019 Outline Introduction Micro RNA s Epigenetic DNA Methylation In silico study Bioinformatics Examples Epigenetic  refers to heritable changes in gene expression active versus inactive genes that does not involve changes to the underlying DNA sequence a change in . Kevin Ferriter. Mariah Minder. From Yesterday…. Do you think your brain cell and your blood cell have the same DNA sequence?. Genetics. Every cell contains all of your DNA. Not every cell expresses all of your DNA. :. DNA . methylation. II. DNA . methylation. in plants (Ch9). Differences between plants and animals. Auxotroph . vs. . heterotroph. Sessile . vs. . mobile. Motionless and rigid . vs. . migrating and flexible cells. the process by which a trait/gene changes function; the gene has been . co-opted to do a new job. Gene Co-option. Inheritance of Acquired Characteristics. Epigenetics turns on/off genes. http://cnx.org/content/m26565/latest/graphics35.jpg. Daniel Messinger. , Ph.D.. Messinger. Hmmm…. ‘Mothers . who were . pregnant during a 1944 famine in the . Netherlands. were . more likely to have children—and grandchildren—prone to heart disease, diabetes, and obesity. . CpG. Island . landscape (part 2). Héctor. Corrada Bravo. CMSC858P Spring 2012. (many slides courtesy of Rafael Irizarry). How do we measure DNA methylation?. Microarray Data. One question…. Where do we measure? . . Samudra. K. . Wijeratne. , Ph.D.. Dept. of Nutrition and Health Sciences, UNL. Processes in . Epigenetics. The . study of heritable changes in gene expression or cellular phenotype caused by mechanisms other than changes in the underlying DNA . How do we make this work?. Dr. Paul S. Anderson. NYANP. 2017. (c) PS Anderson - www.ConsultDrA.com - 2017. 1. Dr. Anderson - Disclosures. Ownership interest in:. • Advanced Medical Therapies Clinic Seattle, WA. of . lncRNAs. in. . Normal Development and Complex Diseases. . R. Michael Sheetz, PhD. . Center for Computational Sciences. . (Long) Non-Coding RNAs . . . Characteristics of . cancer. Khanmi. . Kasomva. ,. Ph.D. . Research . Scholar,. Biotechnology & Molecular Biology Unit, . ERI, . Loyola . College. Chennai, . Inida. .. . . . What we will be discussing about. NON-CODING RNAs (. nc. RNAs) : MICRORNAs AND CANCER. MICRORNAs. . (. MiRs. ) AND CANCER. Outline of Presentation. Non-coding RNAs (. ncRNAs. ) and . microRNAs. . (. MiRs. )-background and functions. Charis Girvalaki. ECPC Director. European Cancer Patient Coalition. . Every year, more than . 3 million. . people are diagnosed with cancer. An estimated . . 3.9 million . people were faced with a diagnosis of cancer and . miRNA. plays in p53 gene expression. . and regulation. Bryce Kirby. The tumor suppressor p53. Specialized protein in cells. Keeps genomic stability. p53 mutations. Highly susceptible to genetic mutation. Azeez Farooki, MD. Attending Physician, Clinical Member. Memorial Sloan Kettering Cancer Center. New York, NY. Objectives. Elucidate the problem of aromatase inhibitor induced bone loss and increased risk of fractures in breast cancer. Boting Ning. Poster #:. Biological Function. Target Genes. miRNAs. NES = . 1.49. P value . =. 0.000. 5. Using nasal miRNA sequencing data, we have identified six miRNAs that were negatively correlated with their predicted target genes and were differentially expressed in patients with malignant IPNs.