PPT-microRNA , Cancer Epigenetics and

Bioinformatics SPRING 2019 BIO307 Jasmin Šutković 2 9th May 2019 Outline Introduction Micro RNA s Epigenetic DNA Methylation In silico study Bioinformatics Examples Epigenetic  refers to heritable changes in gene expression active versus inactive genes that does not involve changes to the underlying DNA sequence a change in . Kevin Ferriter. Mariah Minder. From Yesterday…. Do you think your brain cell and your blood cell have the same DNA sequence?. Genetics. Every cell contains all of your DNA. Not every cell expresses all of your DNA. -What is epigenetics? -Epigenetics and us -Past, present, and future You Are What Your Mother Ate:What is Epigenetics?Daniel Lieber DNA is the Source of Heritable Information in the Cell organism Crea Mitchell Gaynor, MD. Founder and President, . Gaynor Integrative Oncology. Assistant Clinical Professor of Medicine,. Weill-Cornell Medical . College. Scientific Advisor. Environmental Health Trust. Cancer and Environment. Alexandre . Iscaife. ; Denis Reis Morais; Sabrina Thalita Reis; Nayara Izabel Viana, . Andre. . Bordini. ; Daniele . Janolli. ; Nelson . Dip. ; Miguel . Srougi. ; Katia Ramos Moreira Leite . Laboratory of Medical Research – LIM 55, Urology, University of Sao Paulo, Sao Paulo, Brazil. CpG. Island . landscape (part 2). Héctor. Corrada Bravo. CMSC858P Spring 2012. (many slides courtesy of Rafael Irizarry). How do we measure DNA methylation?. Microarray Data. One question…. Where do we measure? . . Samudra. K. . Wijeratne. , Ph.D.. Dept. of Nutrition and Health Sciences, UNL. Processes in . Epigenetics. The . study of heritable changes in gene expression or cellular phenotype caused by mechanisms other than changes in the underlying DNA . Downregulated miRNAs. 870. 49. 68. microRNA. Fold change. in regulation . Target genes. Reference . miR-129 . up 6.46 . CDK6, SOX4, GALNT1, APC, Rab11, EIF2C3, CAMTA1. 1, 2, 3, 4, 5, 6. miR-519e* . up 3.49 . http://www.knowabouthealth.com/wp-content/uploads/2010/06/mcdonalds_.jpg. http://emilyscarenhealth.wordpress.com/2011/10/04/attention-a-must-read-for-smokers/. Can “. nuture. ” change “nature” ?. nuture. ; how our environment talks to us, sometimes forever.. Nessa. Carey, The Epigenetics Revolution (2012). The epigenetics revolution is underway.. Nessa. Carey, The Epigenetics Revolution (2012). Epigenetics comprises (hereditary) changes in gene expression without altering the DNA sequence . Epigenetics is a biological subdiscipline that deals with questions of development, heredity, gene regulation and evolution . cancer. Khanmi. . Kasomva. ,. Ph.D. . Research . Scholar,. Biotechnology & Molecular Biology Unit, . ERI, . Loyola . College. Chennai, . Inida. .. . . . What we will be discussing about. NON-CODING RNAs (. nc. RNAs) : MICRORNAs AND CANCER. MICRORNAs. . (. MiRs. ) AND CANCER. Outline of Presentation. Non-coding RNAs (. ncRNAs. ) and . microRNAs. . (. MiRs. )-background and functions. miRNA. plays in p53 gene expression. . and regulation. Bryce Kirby. The tumor suppressor p53. Specialized protein in cells. Keeps genomic stability. p53 mutations. Highly susceptible to genetic mutation. ‘Epi’: On top of. . Definition:. The . study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself.. DNA. How many cell types are in the human body?.