PPT-Optical Activity of Chiral Epoxides:

Influence of Structure amp Environment on Intrinsic Chiroptical Response Paul M Lemler Clayton L Craft amp Patrick H Vaccaro Department of Chemistry Yale University 225 Prospect Street New Haven CT 065208107 USA . C344. Overview. Asymmetric catalysis. Lab overview. Organometallic reactions. Chiral GC analysis. Optical Activity. Asymmetric Catalysis. Asymmetric Synthesis. Stereoselectivity. . Diastereomeric. excess. . Ethers are relatively unreactive.. Ethers are often used as solvents in organic reactions.. Ethers oxidize in air to form explosive hydroperoxides and peroxides.. “Crown” ethers are useful as enhancers in nucleophilic substitution and other reactions. Structure. Ethers have two organic groups (alkyl, aryl, or vinyl) bonded to the same oxygen . atom.. R groups are identical = symmetrical ether. R groups are different = unsymmetrical ether. Oxygen is . Optical isomers rotate plane polarised light in opposite directions: . one rotates light clockwise and the other anticlockwise. . A mixture containing equal amounts of each isomer is known as a . racemic mixture. Toru Kojo . (. Bielefeld U.. ). . . with:. K. Fukushima, Y. Hidaka, L. . McLerran. , R.D. . Pisarski. 1. /11. . (Confined). (. arXiv. : . 1107.2124). (Confined). Interweaving Chiral Spirals. Toru Kojo . Luca Evangelisti and Walther Caminati. Dipartmento di Chimica “Giacomo Ciamician”, Universita Di Bologna. David Patterson. Department of Physics, Harvard University. Yunjie Xu and . Javix. Thomas. Lemler. , & Patrick H. Vaccaro. The Role of Ring-Size Morphology on Cyclic Amines. Department of Chemistry, Yale University. 225 Prospect St. New Haven, CT . 06511 USA. Intrinsic Optical Activity and Conformational Flexibility: . The term isomerism refers to compounds that have the same molecular formula but different arrangement of atoms.. Structural isomerism- isomers in which atoms and functional groups are attached in different ways. . that optical isomerism is a result of chirality in molecules with a . single chiral . centre. understand . that optical isomerism results from chiral centre(s) in . a molecule with . asymmetric carbon atom(s) and that optical isomers are object . Prof. Diaconescu Group Abstract:Biodegradable polymers are a potential solution for the worldwide "white pollution" issue. Lactones and epoxides are promising monomers to construct such polymers, and, . . Isomers . are molecules that have the same molecular formula, but have a different arrangement of the atoms in space. . What are . stereoisomers. In . stereoisomerism, the atoms making up the isomers are joined up in the same order, but still manage to have a different spatial arrangement. Optical isomerism is one form of stereoisomerism.. Ethers and Their Relatives. An . ether. . has two organic groups (alkyl, aryl, or vinyl) bonded to the same oxygen atom, R–O–R. . Diethyl ether is used industrially as a solvent. Tetrahydrofuran (THF) is a solvent that is a cyclic ether . Chirality, Isomerism, & Stereoisomerism. Lecture No.. 1. What is the difference between an enantiomer and a diastereomer?. Enantiomers and diastereomers are two types of stereoisomers. Enantiomers include mirror images and non-superimposable chiral centers. Diastereomers contain non-superimposable chiral centers, but are not mirror images. Depending on the number of stereocenters, there could be far more than 2 compounds.. Geometric . Isomers/(. Cis. /Trans). Optical Isomers. Enantiomers. Diastereomers. 4. Types of Isomers. C. 4. H. 10. C. 4. H. 10. Stereoisomer/(Geometric. ). Constitutional/(Structural). Geometric/. Cis.