PPT-Mutations What is a mutation?

Changes in the genetic material Mutations can occur in two different types of Cells 1 Somatic body cells 2 Gamete sex or germ cells Mutations in somatic cells Usually result in killing that body cell only. Updated Summer 2015. by J. D. Hendrix. Mutations: Definitions. Lethal . mutation: results in death of the cell, and therefore cannot be propagated or studied. Conditional mutation: One that is expressed only under certain environmental conditions; for example, a temperature-sensitive mutation. Jessica Hawley. Compiled . By: . C. Kohn, Waterford, WI. Objectives. Identify and analyze impacts of mutation.. Interpret impacts of mutation.. Analyze genetic information to determine mutations.. Work on SAE Record Books.. Nobody’s perfect all the time . About 1/10 billion base pairs end up with a error or mutation . Mutation: Mistake in DNA replication or an environmental effect that . results. in a change to the nitrogenous bases in DNA or RNA. . Dun . dun. dun!!!!! . Nobody’s perfect all the time . About 1/10 billion base pairs end up with a error or mutation . Mutation: . Mistake in replication or environmental effect that results in a c. Nobody’s perfect all the time . About 1/10 billion base pairs end up with a error or mutation . Mutation: Mistake in DNA replication or an environmental effect that . results. in a change to the nitrogenous bases in DNA or RNA. . Given a mutation, identify its type. Predict how a mutation will affect a protein.. Mutations. Changes in genetic material (DNA). 2 main types of mutations. Point mutation- change in one or a few nucleotides (letters). How does it happen???. Environmental Influences . such . as: . Chemicals or UV Rays. Inherited: mutations can be passed down from . parent. to . offspring. During copying of . DNA. , . mistakes. can occur. Understand how they occur. Analyze the different types of mutations. Understand how mutations affect amino acid sequences and proteins. Objective. Central Dogma. DNA is transcribed into RNA, RNA is translated into proteins. Small-scale mutations. Missense mutations. Nonsense mutations. Silent mutations. Frameshift mutations. Large scale mutations. Causes. Mutagens. The results of mutation. Mutations. Genetic mutations are changes in the DNA sequence, caused by various mechanisms.. The types of proteins an organism possesses depend upon the . sequence of nucleotides. The two main types of gene mutations include:. Point mutation: one base pair is replaced for another base pair.. permanent change . in the DNA sequence of a gene. .. . Mutations . in a . gene's DNA sequence. can alter . the amino acid sequence . of the . protein. encoded by the gene.. GOOD BAD NEUTRAL. What if it’s NOT just the number?. Gene Mutations. Damaged Chromosomes . –. sometimes a portion of a gene or chromosome is lost or damaged during meiosis. Gene mutation. – a mutation that affects the gene. AACR Annual Meeting 2012. Major Symposium: Designing Rational Combination Therapy for Cancer. Josh Stuart, UC Santa Cruz. Apr 3, 2012. Disclosure. SAB for Five3 Genomics. Overview of pathway-guided approach. starts and is usually fatal by age 4 or 5 years.Our patient presented with early infantile-onset of intractable seizures and progressive neurological deterioration leading to death at the age of 4 yea