PPT-GENETIC CODE FILE 8: POINT MUTATIONS

1 In a mRNA sequence wt there is a triplet UUU After a mutation the triplet changes in UUA What kind of mutation happened and which effects have the mutation on the protein encoded by the gene. Changes in . DNA. that affect genetic information. Gene Mutations. Point Mutations – changes . in one or a few. nucleotides. Substitution. THE FAT CAT ATE THE RAT. THE FAT HAT ATE THE RAT. Insertion. or. How a perfectly good system can go wrong go wrong go wrong. There are 2 types of mutations. 1)Chromosomal rearrangements. . There are too many or too few chromosomes. (nondisjunction and polyploidy). Mutations are changes in the genetic material. . Mutations may be genetic mutations or chromosomal mutations.. Genetic Mutations occur in the “code” on DNA or mRNA. Mistakes in . copying the DNA :. By Karl . Menzel. Is rearrangements or Point Mutations Faster. Synteny. Blocks and Chromosomes. Mouse Human. Chimp Human. Data Reading and Sliding Window. Human vs Chimp. Human vs Mouse. Mutation. Permanent change in the genetic material of an organism. All mutations in gametes are inheritable because they are copied during DNA replication. Somatic cell mutations occur in body cells. Jessica Hawley. Compiled . By: . C. Kohn, Waterford, WI. Objectives. Identify and analyze impacts of mutation.. Interpret impacts of mutation.. Analyze genetic information to determine mutations.. Work on SAE Record Books.. Dun . dun. dun!!!!! . Nobody’s perfect all the time . About 1/10 billion base pairs end up with a error or mutation . Mutation: . Mistake in replication or environmental effect that results in a c. Given a mutation, identify its type. Predict how a mutation will affect a protein.. Mutations. Changes in genetic material (DNA). 2 main types of mutations. Point mutation- change in one or a few nucleotides (letters). Small-scale mutations. Missense mutations. Nonsense mutations. Silent mutations. Frameshift mutations. Large scale mutations. Causes. Mutagens. The results of mutation. Mutations. Genetic mutations are changes in the DNA sequence, caused by various mechanisms.. Conditional mutations. Point mutations. In . point mutations . the sequence of the DNA has been altered at a single position. Where this change consists of replacing one nucleotide by another, it is known as a . MISTAKES IN DNA. A MISTAKE CAN BE:. 1. A point mutation – substitution, addition, or removal of a single DNA base.. 2. A . frameshift. mutation – . a point mutation due to an addition . or deletion of a DNA base that causes a major change in the genetic code.. hM3D(. Gq. ) . is . Gq. coupled DREADD. It is derived from human . muscarinic. receptor M3 sequence with two point mutations (. Y149C, A239G. ). hM. 4. D(. Gi. ) . is . Gi. coupled DREADD. It is derived from human . Science. Learning intention. To understand the different types of mutations. . You will need. A pen and a piece of paper or a laptop to record your answers. . You may need the internet to search for answers. . There are two basic types of mutations:. Gene mutations - mutations that produce changes in a single gene. Chromosomal mutations - mutations that produce changes in whole chromosomes. Gene mutations .