PPT-High-throughput genomic profiling of tumor-infiltrating leukocytes

Presented by Bryan Shaw Background TIL are a part of tumors and are well know to have major roles in cancer biology TIL are vital in tumor growth cancer progression and response to therapy Figure 1 Current and emerging techniques for evaluating TIL composition in solid tumors. microlens. array. Antony Orth and Kenneth . Crozier. 8 . May. CLEO . 2012. Microscopy with lens arrays. What is high . thoughput. microscopy?. Experimental setup – . confocal. system. Lens array characteristics, resolution. Tom O’Regan. September . 2014. HIQA: Risk Profiles. Our Risk . P. rofile . tool . is . core to responsive regulation and in large part informs how the Authority responds to risk in designated . centres. analysis. SNP/genomic signature. Clinical sampling. Personalized chemotherapy. Personalized Targeted therapy. Personalized RNA therapy. Personalized radiation therapy. drugs. Targeted molecules. s. iRNA. Harlan Robins. 1,2. Cindy Desmarais. 2. , Chris Carlson. 1,2. Fred . Hutchinson Cancer Research . Center, Seattle, WA. 1. , Adaptive . TCR. Technologies, Seattle, WA. 2. For additional information about . Ben Ho Park MD PhD. Johns Hopkins University. Financial Disclosures. I have financial relationships with commercial entities that are relevant to the content of this presentation.. Royalties from Horizon Discovery, LTD. Genomic Medicine. In announcing on June 26, 2000, that the first draft of the human genome had been achieved, President Clinton said it would “revolutionize the diagnosis, prevention and treatment of most, if not all, human diseases.”. Understanding New Tools from Federal Chemical Testing Programs . Linda Birnbaum. , Ph.D., D.A.B.T., A.T.S.. Director, National Institute of Environmental Health Sciences and National Toxicology Program. A CERN . openlab. / Intel collaboration. Niko Neufeld, CERN/PH-Department. niko.neufeld@cern.ch. HTCC in a nutshell. Apply upcoming Intel technologies in an Online / Trigger & DAQ context. Application domains: L1-trigger, data acquisition and event-building, accelerator-assisted processing for high-level trigger. Sunita Mittal. Learning Objectives. Introduction to WBCs. Myelopoiesis & its steps. Neutrophil characteristics. Inflammation and signs of inflammation. Role of Neutrophil in inflammation/infection. Frontend. Dan Bradley. Center for High Throughput Computing. Condor Flocking. CHTC. Condor. Pool. CS. Nuclear Eng.. Genomics. CMS Tier 2. Atlas Tier 3. Chemical Engineering. IceCube. Medical. Physics. in Advanced Solid Tumors. EDRN Biomarker Development Lab. Arul M. Chinnaiyan, M.D., Ph.D.. American Cancer Society Research Professor. Howard Hughes Medical Institute. Sequencing. Buccal swab . or. Blood. Global High-Incidence Regions Identifies Crucial Genes and Potential Cancer Markers. Contributors: . Fazlur Rahman Talukdar. , Sheila C. Soares Lima, Rita . Khoueiry. , . Ruhina. Shirin . Laskar. , . 11635 . Northpark. Drive, Suite 250, Wake Forest, NC 27587. Gene . expression profiling . for . targeted cancer . treatment. Luminita. . Castillos. 1. , PhD, MBA, Francisco Castillos. 1. , III, MD and Anton Yuryev. Intervista a Federico . Cappuzzo. Background:. Programmed death-ligand 1 (PD-L1) expression on tumor cells (TC) or tumor-infiltrating immune cells (IC) is associated with OS, PFS and ORR in pts with advanced NSCLC treated with atezolizumab (anti-PDL1, MPDL3280A; Spigel et al, Spira et al, ASCO 2015), indicating that PD-L1 expression on both TC and IC is important for anti-tumor immunity. However, these 2 distinct expression patterns suggest the existence of previously unidentified NSCLC subtypes with distinct immunologic profiles. .