PPT-Genome evolution Lecture 2:

population genetics I models and drift Reading Course slides on the web Hartl and Clark Principle of population genetics Rick Durret Probability models for DNA sequence evolution Gillespie Pop Genetics A concise guide. Jeroen. . Raes. , Jan O . Korbel. , Martin J . Lercher. , Christian von . Mering. and Peer Bork. Presented by Daehwan Kim. Outline. Genome size. Genome sizes of Archaea, Bacteria, and Eukaryotes. Factors affecting genome and genome sizes . Mayo/UIUC Summer . C. ourse in Computational Biology. Session Outline. Genome sequencing. Schematic overview of genome assembly. (a) DNA is collected from the biological sample and sequenced. (b) The output from the sequencer consists of many billions of short, unordered DNA fragments from random positions in the genome. (c) The short fragments are compared with each other to discover how they overlap. (d) The overlap relationships are captured in a large assembly graph shown as nodes representing . (as told by Michael Lynch). Genome size and complexity varies across the tree of life. Lynch 2007. Some Big Questions. What is the relationship between genomic and organismal size/complexity?. Are genome size changes adaptive, or passively acquired?. A mechanism for change in populations.. Any change in the . inherited . traits within a population across generations. Individuals better adapted to their environment tend to survive and . produce more offspring. What do we use in order to determine evolutionary relationships?. Fossil Record. Anatomical Evidence. Molecular Evidence. Embryological Evidence. Evidence for Evolution. Fossil Record. Evidence for Evolution. What you need to know:. The major goals of the Human Genome Project.. How . prokaryotic genomes compare to eukaryotic genomes. .. Applications of bioinformatics to medicine, evolution, and health.. The activity and role of transposable elements and . October 1, 2019. Jeremy . Glasner. PhD. Science, 1997. Variation among genomes arises as they diverge from a common ancestor. Point mutations introduce small changes in one or the other lineages (SNPs, small insertions and deletions).. xxia@uottawa.ca. http://dambe.bio.uottawa.ca. Definitions. Genome: the . entire complement of genetic material carried by an individual. Transcriptome with two definitions:. the . entire set of . transcribable sequences from the genome (operationally all RNA sequences from annotated productive genes in a genome). of . the Red . Queen. CfE. . Advanced Higher Biology. Unit . 2: . Organisms and Evolution. SQA mandatory key information. A change in the traits of one species acts as a selection pressure on the other species. . [22]. The pattern of blocks was assessed to see whether theirarrangement in the ancestral genome prior to duplicationarrangement in the ancestral genome prior to duplicationequally parsimonious series Evolution. – when a species of plants or animals adapts to their environment in order to survive over a long period of time. Key points!. Species. Plants or Animals. Adaptations. In order to survive. G-OnRamp Beta Users Workshop. Wilson Leung. 07/2016. Outline. Obtain genome assemblies from NCBI. Transfer . large genomics datasets to Galaxy. Common bioinformatics file formats . D. atatypes in Galaxy. . The process by which organism change over time. Based on science, not opinion.. Darwin. :. Evolution is descent with modification. Evolution. :. changes through time. Species accumulate difference. . The process by which organism change over time. Based on science, not opinion.. Darwin. :. Evolution is descent with modification. Evolution. :. changes through time. Species accumulate difference.