PPT-Cancer Sequencing Credits for slides: Dan

Newburger What is Cancer Definitions A class of diseases characterized by malignant growth of a group of cells Growth is uncontrolled Invasive and Damaging Often able to metastasize An instance of such a disease a malignant tumor. brPage 1br Blatantly Commandeered Slides PacBio RS Single Molecule Sequencing Tristan De Buysscher UNC Center for Bioinformatics NGS 2013 The Hominid Lineage. Archaeology – “the scientific study of material remains (as fossil relics, artifacts, and monuments) of past human life and activities”. Studies the time period starting at the Paleolithic time until the advent of literacy . DNA pol error rate . ~. 10. -9. per base . copied. How many errors in a . “typical” . somatic cell?. Most errors don’t have detectable effects. But some errors do: . . oncogenes. N. . – dominant. Andrew Gentles. CCSB NGS workshop. September 2012. You’ve slogged through QC, trimming, alignment, realignment, variant calling. What next ?. Mutational processes molding the genomes of 21 breast cancers/The life history of 21 breast cancers. Credits for slides: Dan . Newburger. What is Cancer?. Definitions. A class of diseases characterized by malignant growth of a group of cells. Growth is uncontrolled. Invasive and Damaging. Often able to metastasize. Ready for Prime Time?. DANA-FARBER . CANCER INSTITUTE. Nikhil C. Munshi, MD . Professor of Medicine . Harvard Medical School. Boston VA Healthcare System. Director . Basic and Correlative Sciences. Dana-Farber Cancer . Next Generation Sequencing. Hanlee Ji, M.D. . ã . Stanford University. Overview. Principles of next generation . DNA sequencing. Analysis of genetic variation and research applications. Harlan Robins. 1,2. Cindy Desmarais. 2. , Chris Carlson. 1,2. Fred . Hutchinson Cancer Research . Center, Seattle, WA. 1. , Adaptive . TCR. Technologies, Seattle, WA. 2. For additional information about . for Colorectal . Cancer. Ulrike (. Riki. ) Peters. Fred Hutchinson Cancer Research Center. University of Washington. Overview. Significance and rationale. . Current efforts on rare and less frequent variants. in Advanced Solid Tumors. EDRN Biomarker Development Lab. Arul M. Chinnaiyan, M.D., Ph.D.. American Cancer Society Research Professor. Howard Hughes Medical Institute. Sequencing. Buccal swab . or. Blood. Clinical Implementation in CLIA/CAP facility. Shashikant Kulkarni, M.S (Medicine)., Ph.D., FACMG. Associate Professor of Pediatrics, Genetics, Pathology and Immunology. Medical Director of Genomics and Pathology Services. Tim Graubert, MD. Division of Oncology, Stem Cell Biology Section. Washington University School of Medicine. Siteman Cancer Center. Genome Center at Washington University. Genome Center Leadership. Rick Wilson. for suspected cancer Information for patients and family members Genomic Medicine Service NHS What is your genome? Your genome is the information needed to build the human body and keep it health Definitions. A class of diseases characterized by malignant growth of a group of cells. Growth is uncontrolled. Invasive and Damaging. Often able to metastasize. An instance of such a disease (a malignant tumor).