PPT-GREML: Heritability Estimation Using Genomic Data

GREML Heritability Estimation Using Genomic Data Rob Kirkpatrick amp Matt Keller March 9 th 2018 1 Overview Regression Estimates of V A Genomic Relatedness Matrices GREML Combining GREML amp SEM. Lipika. Ray. 4th . June 2010. Heritability:. Phenotype (P) = genotype (G) + environmental factors (E). (observed) (unobserved) (unobserved). Variances:. Heritability is defined as ratio of variances, by expressing the proportion of the phenotypic variance that can be attributed to variance of genotypic values:. Early genomic theory. Nejati-Javaremi. et al (. 1997. ) tested use of genomic relationship matrix in BLUP. Meuwissen et al (. 2001. ) tested linear and nonlinear estimation of . haplotype. effects. Biases, confounding factors, current methods, and best practices. Luke Evans, Matthew Keller. Background – What Matt Keller presented. GREML-SC: single genetic relatedness matrix (GRM) to estimate heritability (. New Statistical Approaches. Or . Zuk. . Broad Institute of MIT and Harvard. orzuk@broadinsitute.org. www.broadinstitute.org/~orzuk. Genome . Wide Association Studies (GWAS). 2. l. ength: ~3x10. 9. ACCGAGAGGGTT. Jack K. . Okamuro. National Program Leader for Plant Biology, . Crop . Productoin. & Protection, USDA-ARS. ARS Administrator’s Council Meeting. December 5, 2012. Beltsville, MD. Challenge. Food Security & Sustainability. 1. . To develop methods for determining effects of acceleration noise and orbit selection on geopotential estimation errors for Low-Low Satellite-to-Satellite Tracking mission.. 2. Compare the statistical covariance of geopotential estimates to actual estimation error, so that the statistical error can be used in mission design, which is far less computationally intensive compared to a full non-linear estimation process.. exposomic. findings to realize the precision medical care in Tohoku Medical Megabank. 0. Division of . Bioclinical. . Imformatics. Tohoku Medical Megabank Organization, . Tohoku University. Hiroshi Tanaka, . ForewordOne secret weapon has helped beat every disease outbreak over the last century but it is not masks or social distancing lockdowns or even vaccines Instead it is data Data tells us which masks George Wiggans, CDCB Technical Advisor. Highlights of U.S. system. Over half a million animals genotyped in 2016. 67% of AI breedings to genomic bulls. Genomic relationship between genotyped cows and marketed bulls available. common . disease. AKA . –. everything is much harder in a binary trait. Naomi Wray. 1. Missing heritability . psychiatric disorders. N cases. N loci. h. 2. SNP-h. 2. Schizophrenia. 67K. 245. 80. 26. Dina Paltoo, Ph.D., M.P.H.. NIH Office of Science Policy. Laura Lyman Rodriguez, Ph.D.. National Human Genome Research Institute. October 4, 2017. Housekeeping. Participants must register to join the webinar. Loic Yengo, PhD. Institute for Molecular Bioscience. The University of Queensland. l.yengo@imb.uq.edu.au. 1. What quantitative genetics tells us about heritability?. Part 1. 2. Outline. Definition of heritability (and genetic correlation). ETH Zürich. October 1, 2015. Mathias Humbert . Joint . work. with Erman Ayday, Jean-Pierre Hubaux, . Kévin Huguenin, Joachim Hugonot, Amalio Telenti. (. Human. ) System Security. 0. 1. 0. 0. 1. 1. Associate . Professor. Dept. of Genetics and Animal Breeding. PSTU, . Barishal. campus. Overview. Definition. Scale of Heritability. Example. Uses of Heritability. Limitations of Heritability. Methods of Estimation of Heritability.