Epilepsy Prevalence in the United States Age and Prevalence of Epilepsy Success in AED Regimens What Is Rational Polytherapy Proposed MOA of AEDs Enhance GABAergic Neuromodulation Proposed MOA of AEDs ID: 746325
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Slide1
New Antiepileptic DrugsSlide2
Program GoalsSlide3
EpilepsyPrevalence in the United StatesSlide4
Age and Prevalence of EpilepsySlide5
Success in AED Regimens (%)Slide6
What Is Rational Polytherapy?Slide7
Proposed MOA of AEDsEnhance GABAergic NeuromodulationSlide8
Proposed MOA of AEDsReduce Glutamate-Mediated Excitatory ModulationSlide9
Synergistic Drug CombinationsSlide10Slide11
Lacosamide PK ProfileSlide12
Lacosamide as Adjunctive TherapyMost Common TEAEs Slide13
Lacosamide Monotherapy Conversion TrialKM-Estimated 112-Day Exit RateSlide14
Eslicarbazepine AcetateApproved as Monotherapy or Adjunctive Therapy for Patients With POSSlide15Slide16
Eslicarbazepine PharmacokineticsSlide17
Eslicarbazepine as Adjunctive Therapy50% or Greater Reduction in Seizure FrequencySlide18
Eslicarbazepine as Adjunctive TherapyMost Common TEAEsSlide19Slide20Slide21Slide22
Proposed MOA of AEDs Slide23
PerampanelSlide24Slide25Slide26
Perampanel for Refractory PGTC SeizuresSlide27Slide28
New SV2A ModulatorsSlide29
Molecular Targets of AEDsWhere Does This Leave Us?Slide30
AbbreviationsSlide31
Abbreviations (cont)