PPT-Novel signaling paradigm regulating TOLL-like receptors in innate immune

cells Samar Abdulkhalek and Myron R Szewczuk Dept Biomedical and Molecular Sciences Queens University Kingston K7L 3N6 Ontario Canada speaker A novel signaling paradigm for cell surface TLR4 and intracellular TLR7 and TLR9. Evading the Immune response. Ryan Rego . Antibiotic . resistance: World on cusp of 'post-antibiotic era'. The world is on the cusp of a "post-antibiotic era", scientists have warned after finding bacteria resistant to drugs used when all other treatments have failed. . Evolutionary View. Epithelial barriers to infection. Four main types of innate recognition . molecules:TLRs. , CLRs, NLRs, RLRs. NF-. . B, the master transcriptional regulator of inflammation . Inflammation and recruitment of phagocytes. Control of the Cell Cycle. Intracellular signaling. Pathways initiated by ligand binding to receptors, usually plasma membrane proteins. Modulate cell growth, metabolism, death, differentiation, movement, and invasion. Kuby Immunology. , . 7e: Chapter 3. Essential Concepts – 1. A cellular signal is any event that instructs a cell to change its metabolic or proliferative state. Signals are usually generated by the binding of a ligand to a complementary cell-bound receptor. Kuby. . Immunology. , . 7e: Chapter 1. A historical perspective of immunology. What is immunity?. Immunity is the state of protection against foreign pathogens or substances (antigens). Latin term . Learning objectives. By the end of this session student will be able to. . Define innate immunity, acquired immunity. . To understand cells involved in . innate . and acquired . immunity. IMMUNITY. 1. st. Lecture. Definitions. Immunity. . (. Latin . “. immunitas. ”) is a universal biological phenomenon that develops many programs based on the unique genotype of the body (“self”) in foreign surroundings, from the birth of the body to its death. There are two major types of immunity, . The Immune System. The immune system is a group of cells & soluble molecules, which interact & distinguish patterns in the body as “self” or “non-self,” in order to eliminate those that are “non-self.”. Abbas. University of California San Francisco. FOCiS. Lecture outline. Components of innate immunity. Recognition of microbes and dead cells . Toll Like Receptors. NOD . Like Receptors/. Inflammasome. Dr. . M.A.Thomas. . FUNCTIONS . OF THE IMMUNE SYSTEM. :. Recognize. , destroy and clear a diversity of pathogens. .. Initiate . tissue and wound healing processes. .. Recognize . and clear damaged self components. Introduction. Cell signaling: . a biological mechanism that occurs in cells which gives cells an ability to receive or generate the signals in response to their surrounding environment.. Cell to cell communication . innate immunity. Prof dr. . Ihsan. . Edan. . Alsaimary. department of microbiology – college of medicine – university of . basrah. Mobile : 07801410838 - . e.mail. : ihsanalsaimary@gmail.com. There are lots of . micoorganisms. that we . encounter everyday . through breathing, touching, and eating. . Most are detected and . destroyed within minutes or hours . by defense mechanisms that do not rely on the clonal expansion of antigen-specific lymhphocytes. . Organs and . cells. Peter Kelleher. Senior Lecturer, Imperial . College London, . Chelsea & Westminster . campus. Learning objectives . Illustrate the importance of immunology for human health..  .