PPT-Appropriate Use of Platelets update 2019

Dr Brian Tehen Stephanie Ditcham Medical Director for Qualityamp Transformation Blood Health Advisor BCUHB WBS Briantehanwalesnhsuk Blood Health National Oversight Group. Platelets are small cell fragments in the blood that help control bleeding. They plug small holes in blood vessels and assist in the clotting process. Why should I become a platelet donor? Every day What distinguishes clay a potter uses from plain . ol. ’ dirt?. Three Essential Properties. Plasticity. Porosity. Vitrification. PLASTICITY. The ability to hold its . form. while at the same time be . Joanna Rupa-Matysek. Hemostatic. System - . general. . information. Normal . hemostatic. system . vessel wall. circulating blood platelets. blood coagulation and . fibrynolysis. Bleeding. . Diathesis. University. Faculty of Applied Medical Sciences. Department Of Medical Lab. Technology. 3. rd. Year – Level 5 – . AY 1434-1435 . 1. Hematology – 2, MLT 307. Bleeding disorders. . caused by . INFLAMMATION AND . IMMUNITY. Authors: Radu Andrei . Tomai. . . Cluj. . . . . Antoine . Joubert. . . Nantes. Supervisor. : Zsófia Mezei-Leprán, MD, . PhD. . Platelet Counts. Vary with . Age (slight decrease in mean with increased age). Sex (Slightly lower mean in men). Consequences of Misdiagnosis of Inherited Thrombocytopenia. Wrong therapy. Wrong prognosis. “Blood transfusion is like marriage: it should not be entered upon lightly, unadvisedly or wantonly or more often than is absolutely necessary. .” . . –Robert Beal, past director of International Federation of Red Cross. “River of life”. Transports everything that must be carried from one place to another within the body:. Nutrients. Wastes. Heat. Composition of Blood. Blood cells or formed elements:. Red blood cells – transports oxygen. Waterford, WI. A wound occurs when the a break in tissue occurs. . This can be because of trauma.. It can also be intentional, such as is the case during a surgery.. There are . five kinds . of . wounds (PAAIL).. Elizabeth S. Allen, MD. Outline. Platelets. Problems with Platelets. Pathogen Reduced Platelets. UCSD Implementation Strategy. Objectives. Understand the risks of conventional platelet transfusion. Describe the mechanism and effects of pathogen reduction technology.  . Platelets . are small colorless. ,. Non . nucleated and moderately refractive bodies which are considered to be the fragments of cytoplasm. .. . Diameter. : 2.5 μ (2 to 4 μ). Volume: 7.5 cu μ (7 to 8 cu μ. purpura. (ITP). Immune thrombocytopenia . purpura. (ITP). 1- Chronic ITP: . This is relatively common disorder ,with highest incidence in . women. . 15-50 y. ,it is commonest cause of thrombocytopenia without anemia or neutropenia ,it is usually . Practical Hematology Lab. - LAB . -. Platelet . Satellitism. Morphology. Platelets clumped around neutrophils. .. Found . in. EDTA in vitro induced change of no clinical significance except false low platelet count (in vitro).. Gilead Sciences. Foster City, CA , USA. Activating. PKC-. ε . induces HIV. expression with improved tolerability. This study was funded by Gilead Sciences, USA. Protein Kinase C(PKC) agonists activate latent HIV, but have limited clinical utility due to toxicity. .