PPT-Genetics and Genome Evolution (GGE)

Bioinformatics for Genomics Lecture 5 Advanced clustering Sven Bergmann Department of Computational Biology SvenBergmannunilch Analysis tools for large datasets Standard tools kmeans PCA SVD. http://www.dnapolicy.org/. “A . treatable . disease . like . severe asthma”. “Having a bad . reaction to . certain types of medicine”. No. Yes. “An . untreatable . disease . like . Alzheimer’s”. 1 Street Sweeper. 10 Refuse Trucks. 10 Pickups. 6 . Dump . Trucks. 10 . Transit Busses. 38 Total. Started in 2011 with 4 Refuse Trucks. 19 additional CNG vehicles on ordered which include:. 2 Transit Connects, 4 Pickups, 1 Car, 1 Street Sweeper, 4 Dump Trucks, 1 Knuckle Boom, 6 Transit Busses. From classical genetics to the personal human genome. Classical Genetics:. Gregor. Mendel (1860). Discovered the classical laws of inheritance through his work with pea plants. Mendel’s work . remained unknown. Arend Sidow, Ph.D.. Professor, Departments of Pathology and Genetics, Stanford. An introduction that includes the most important concepts in Genetics and Genome Biology. 1. Genotype. Phenotype. Genetic Testing. DARWIN’S UNDERSTANDING VS. PRESENT DAY. How are inheritable traits passed?. How do variations appear?. Today’s understanding of genes, DNA, variation, and mutations is central to our understanding of how evolution works . 65. Gregor . Mendel crossed a true-breeding tall plant (TT) with a true-breeding . short plant . (. tt. ). What are the possible phenotypes for the offspring. ?. A. . All tall. B. . All short. C. . Ratio of 1 tall : 1 short. Key considerations:. Genes . Chromosomes. C value paradox. Gene regulation. Epigenetics. Transposable elements. DNA . ……..……..mRNA……….…….Protein . Plant . Estimated # genes. Arabidposis. Key considerations:. Genes . Chromosomes. C value paradox. Gene regulation. Epigenetics. Transposable elements. DNA . ……..……..mRNA……….…….Protein . Plant . Estimated # genes. Arabidposis. Dr. Vladimir Teif. BS222 – Genome Science Lecture 1. Welcome to BS222 Genome Science!. Meet your lecturers. Vladimir Teif. (module supervisor). Leonard . Schalkwyk. Patrick . Varga-Weisz. Jordi . Paps. What you need to know:. The major goals of the Human Genome Project.. How . prokaryotic genomes compare to eukaryotic genomes. .. Applications of bioinformatics to medicine, evolution, and health.. The activity and role of transposable elements and . Chapter. 2: . Evolutionary. Computing: the . Origins. Historical perspective. Biological inspiration:. Darwinian evolution theory . (simplified!). Genetics . (simplified!). Motivation for EC . 2. Assistant Professor . Department of Respiratory Care. Rush University. Chicago, Illinois. Author’s Conflicts of Interest. The author disclosed no conflicts of interest. Research sponsor. The sponsor had full access to data. [22]. The pattern of blocks was assessed to see whether theirarrangement in the ancestral genome prior to duplicationarrangement in the ancestral genome prior to duplicationequally parsimonious series G-OnRamp Beta Users Workshop. Wilson Leung. 07/2016. Outline. Obtain genome assemblies from NCBI. Transfer . large genomics datasets to Galaxy. Common bioinformatics file formats . D. atatypes in Galaxy.