PPT-Genetics and Genome Evolution (GGE)

Bioinformatics for Genomics Lecture 5 Advanced clustering Sven Bergmann Department of Computational Biology SvenBergmannunilch Analysis tools for large datasets Standard tools kmeans PCA SVD. To elucidate the structural characteristics of newly arisen gene duplicates at infancy and their subsequent evolutionary properties we analyzed gene pairs with 10 divergence at synonymous sites within the genome of Caenorhabditis elegans Structural Genome sequencing. Next Gen sequencing. Genomics = resources. genome maps. genome sequences. genome clones. DNA microarrays. whole gene collections. functional genomics!. 1980- 1998. 1977- 2003. DNA mapping. From classical genetics to the personal human genome. Classical Genetics:. Gregor. Mendel (1860). Discovered the classical laws of inheritance through his work with pea plants. Mendel’s work . remained unknown. Chapter 21. You must know. How prokaryotic genomes compare to eukaryotic genomes.. Applications of bioinformatics to medicine, evolution, and health.. The activity and role of transposable elements and retrotransposons in generating genetic diversity.. Next Generation Technology . Developments and Applications:. Now and Potential across Healthcare. Eileen Roberts. Thalia Antoniadi. http://www.nbt.nhs.uk/genetics. The changing landscape . Advances in technology are altering the landscape of medical care . Arend Sidow, Ph.D.. Professor, Departments of Pathology and Genetics, Stanford. An introduction that includes the most important concepts in Genetics and Genome Biology. 1. Genotype. Phenotype. Genetic Testing. Key considerations:. Genes . Chromosomes. C value paradox. Gene regulation. Epigenetics. Transposable elements. DNA . ……..……..mRNA……….…….Protein . Plant . Estimated # genes. Arabidposis. Dr. Vladimir Teif. BS222 – Genome Science Lecture 1. Welcome to BS222 Genome Science!. Meet your lecturers. Vladimir Teif. (module supervisor). Leonard . Schalkwyk. Patrick . Varga-Weisz. Jordi . Paps. What you need to know:. The major goals of the Human Genome Project.. How . prokaryotic genomes compare to eukaryotic genomes. .. Applications of bioinformatics to medicine, evolution, and health.. The activity and role of transposable elements and . Chapter. 2: . Evolutionary. Computing: the . Origins. Historical perspective. Biological inspiration:. Darwinian evolution theory . (simplified!). Genetics . (simplified!). Motivation for EC . 2. Summary of Research Interests. Gene identification and genome annotation. The evolution of genome-sequence compositional properties. Models of protein evolution. The phylogeny of Bacteria. Measures of differentiation from genomic and . xxia@uottawa.ca. http://dambe.bio.uottawa.ca. Definitions. Genome: the . entire complement of genetic material carried by an individual. Transcriptome with two definitions:. the . entire set of . transcribable sequences from the genome (operationally all RNA sequences from annotated productive genes in a genome). [22]. The pattern of blocks was assessed to see whether theirarrangement in the ancestral genome prior to duplicationarrangement in the ancestral genome prior to duplicationequally parsimonious series Iwema. , . PhD, MLS, AHIP. 19. th. March 2014. Molecular Biology Information Service. 1997. Outline. Context. Personal Genomics. Personalized Medicine. Consumer Impact. Context. Broad Timeline of Genetics.