PPT-Signal Transduction:

LigandReceptor Interactions Cell and Developmental Biology Group Goals Integration of quantitative skills in cell biology Modeling cellular responses   Class setup First or second year majors in cell biology. (from Kimura, 1966). Electron micrograph of 3 OHCs. spiral ligament. modiolus. When the basilar membrane vibrates up and down in response to the sound wave, the hair cell cilia are displaced 1. st. in one direction then in the other; i.e., 1. Many factors can affect transduction efficiency. Not all viral particles floating in culture medium can eventually transduce (or infect) the cells. Some additives such as polybrene can enhance the t FOR THE INSULIN MIMETIC ACTIVITY OF NEOHESPERIDOSE. Taro Kimura. , . Eisuke. Kato, Jun Kawabata. Laboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University,. Pratt & . Cornely. , Chapter 10. Terms for Signal Transduction. Ligand. Receptor. Transducer. Effector. Second messenger. Target proteins/DNA. Ligands. Hormones vs Local mediators. Polar (insulin) vs nonpolar (steroidal hormone). Index. Introduction. Discovery. Linkage data from transduction. Specialized transduction. Lytic and Lysogenic Cycle. Introduction. Transduction is the process by which DNA. . is transferred from one bacterium to another by a virus.. . Enzyme-linked . receptors. Nuclear receptors. Stochasticity. in . signalling. .. Enzyme-linked receptors. . signalling. through growth factors, hormones, cytokines. acting locally at very low concentrations (10. Believed to have evolved in prokaryotes and single-celled eukaryotes. Single-celled organisms. Bacteria use communication in quorum sensing. Short distance communication using local regulators. Secrete . Dr. Kevin Ahern. EGFR Signaling, Part 1. Epidermal Growth Factor Receptor (EGFR). EGFR Dimer. Autophosphorylated. Tyrosines in . Cytoplasmic Domain. Signaling Complex. Assembled on . Phosphotyrosines. LO 3.36: The student is able to describe a model that expresses the key elements of signal transduction pathways by which a signal is converted to a cellular response. SP 1.5: The student can re-express key elements of natural phenomena across multiple representations in the domain. More than 4 years experience in developing and analyzing mathematical models of complex bio-chemical reaction networks 10 Journal papers, 1 book chapter, 6 peer-reviewed conference papers, and 7 Z. Huang, Y. Chu, B. Cunha, and J. Hahn, Learning Objectives. Learn the general structure and properties of hormones.. Know the differences between Hormones, Neurotransmitters & enzymes. 3. . Understand . the general properties of signaling molecules (ligands), cell-surface receptors, & intracellular signal transduction components.. General Steps. 1. Receptor activation by extracellular/ intracellular signal. . 2. Binding of adapter proteins to receptor domains. 3. Recruitment of other proteins. 4. Phosphorylation, Ubiquitination, Acetylation etc.. Cellular Signaling. Autocrine Signals . Diffuse from one part of a cell to another part of the same cell. Synaptic signaling. Neurotransmitter is the signaling molecule. Occurs in the animal nervous system.